Re-evaluating the role of epithelial-mesenchymal-transition in cancer progression
| Autor: | Andrew Sulaiman, Lisheng Wang, Zemin Yao |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Population Review Article Biology General Biochemistry Genetics and Molecular Biology Metastasis 03 medical and health sciences 0302 clinical medicine cancer metastasis medicine Epithelial–mesenchymal transition mesenchymal-epithelial transition (MET) education Transcription factor education.field_of_study hybrid EMT/MET Mesenchymal stem cell Cancer General Medicine medicine.disease Phenotype Epithelial-mesenchymal transition (EMT) 030104 developmental biology 030220 oncology & carcinogenesis Cancer cell Cancer research |
| Zdroj: | Journal of Biomedical Research |
| ISSN: | 2352-4685 1674-8301 |
| Popis: | Epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET) are essential for embryonic development and also important in cancer progression. In a conventional model, epithelial-like cancer cells transit to mesenchymal-like tumor cells with great motility via EMT transcription factors; these mesenchymal-like cells migrate through the circulation system, relocate to a suitable site and then convert back to an epithelial-like phenotype to regenerate the tumor. However, recent findings challenge this conventional model and support the existence of a stable hybrid epithelial/mesenchymal (E/M) tumor population. Hybrid E/M tumor cells exhibit both epithelial and mesenchymal properties, possess great metastatic and tumorigenic capacity and are associated with poorer patient prognosis. The hybrid E/M model and associated regulatory networks represent a conceptual change regarding tumor metastasis and organ colonization. It may lead to the development of novel treatment strategies to ultimately stop cancer progression and improve disease-free survival. |
| Databáze: | OpenAIRE |
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