Negative optokinetic afternystagmus in larval zebrafish demonstrates set-point adaptation
Autor: | Fausto Romano, Dennis Lüthi, Ahmed M. Fathalla, Duygu Pul, Kathleen E. Cullen, Ting Feng Lin, Mohammad Hossain Mohammadi, Maurice J. Chacron, Dominik Straumann, Melody Ying-Yu Huang |
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Přispěvatelé: | University of Zurich, Huang, Melody Ying-Yu |
Rok vydání: | 2019 |
Předmět: |
0301 basic medicine
Time Factors Oculomotor system Ocular motor lcsh:Medicine 610 Medicine & health Biology Stimulus (physiology) Eye Models Biological Article 03 medical and health sciences 0302 clinical medicine Reflexes Zebrafish larvae Animals lcsh:Science Nystagmus Optokinetic Zebrafish 1000 Multidisciplinary Sensory Adaptation Multidisciplinary Adaptation Ocular lcsh:R fungi Optokinetic reflex Set point 10040 Clinic for Neurology 030104 developmental biology Larva Reflex lcsh:Q Motor learning Neuroscience Photic Stimulation 030217 neurology & neurosurgery |
Zdroj: | Scientific Reports Scientific Reports, 9 (1) Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019) |
ISSN: | 2045-2322 |
DOI: | 10.1038/s41598-019-55457-4 |
Popis: | Motor learning is essential to maintain accurate behavioral responses. We used a larval zebrafish model to study ocular motor learning behaviors. During a sustained period of optokinetic stimulation in 5-day-old wild-type zebrafish larvae the slow-phase eye velocity decreased over time. Then interestingly, a long-lasting and robust negative optokinetic afternystagmus (OKAN) was evoked upon light extinction. The slow-phase velocity, the quick-phase frequency, and the decay time constant of the negative OKAN were dependent on the stimulus duration and the adaptation to the preceding optokinetic stimulation. Based on these results, we propose a sensory adaptation process during continued optokinetic stimulation, which, when the stimulus is removed, leads to a negative OKAN as the result of a changed retinal slip velocity set point, and thus, a sensorimotor memory. The pronounced negative OKAN in larval zebrafish not only provides a practical solution to the hitherto unsolved problems of observing negative OKAN, but also, and most importantly, can be readily applied as a powerful model for studying sensorimotor learning and memory in vertebrates. Scientific Reports, 9 (1) ISSN:2045-2322 |
Databáze: | OpenAIRE |
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