Predictors of therapy failure in newly diagnosed pulmonary tuberculosis cases in Beira, Mozambique

Autor: Jorge Moiane, Damiano Pizzol, Giovanni Putoto, Claudia Marotta, Kajal D. Chhaganlal, Annalisa Saracino, Francesco Di Gennaro, Walter Mazzucco, Nicola Veronese, Laura Monno
Přispěvatelé: Pizzol, D Veronese N, Marotta C, Di Gennaro F, Moiane J, Chhaganlal K, Monno L, Putoto G, Mazzucco W, Saracino A
Rok vydání: 2017
Předmět:
Genetics and Molecular Biology (all)
0301 basic medicine
Male
Treatment outcome
Antitubercular Agents
lcsh:Medicine
HIV Infections
Settore MED/42 - Igiene Generale E Applicata
Biochemistry
Treatment failure
Body Mass Index
0302 clinical medicine
Therapy failure
Outpatients
Global health
Odds Ratio
030212 general & internal medicine
Treatment Failure
lcsh:QH301-705.5
Mozambique
Coinfection
General Medicine
Prognosis
Tuberculosis
Biochemistry
Genetics and Molecular Biology (all)
Research Note
Educational Status
Female
Adult
Employment
medicine.medical_specialty
Adolescent
030106 microbiology
Newly diagnosed
General Biochemistry
Genetics and Molecular Biology
03 medical and health sciences
Pulmonary tuberculosis
Internal medicine
medicine
Humans
lcsh:Science (General)
Poverty
Tuberculosis
Pulmonary
Adult patients
business.industry
lcsh:R
Malnutrition
medicine.disease
Tuberculosis
Mozambique
Therapy failure
lcsh:Biology (General)
Hiv status
business
lcsh:Q1-390
Zdroj: BMC Research Notes
BMC Research Notes, Vol 11, Iss 1, Pp 1-6 (2018)
ISSN: 1756-0500
Popis: Objective Tuberculosis (TB) remains a major global health issue, ranking in the top ten causes of death worldwide. A deep understanding of factors influencing poor treatment outcomes may allow the development of additional treatment strategies, focused on the most vulnerable groups. Aims of the study were: (i) to evaluate the treatment outcome among TB subjects followed in an outpatient setting and (ii) to analyze factors associated with treatment failure in newly diagnosed patients with pulmonary TB in Beira, the second largest city of Mozambique. Results A total of 301 TB adult patients (32.6% females) were enrolled. Among them, 62 (20.6%) experienced a treatment failure over a 6 months follow-up. On multivariate model, being males (O.R. = 1.73; 95% CI 1.28–2.15), absence of education (O.R. = 1.85; 95% CI 1.02–2.95), monthly income under 50 dollars (O.R. = 1.74; 95% CI 1.24–2.21) and being employed (O.R. = 1.57; 95% CI 1.21–1.70), low body mass index values (O.R. = 1.42; 95% CI 1.18–1.72) and HIV status (O.R. = 1.42; 95% CI 1.10–1.78) increased the likelihood of therapy failure over 6 months of follow-up. In this study, patients who need more medical attention were young males, malnourished, with low income and low educational degree and HIV positive. These subjects were more likely to fail therapy.
Databáze: OpenAIRE
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