The Argus(®) II Retinal Prosthesis System
| Autor: | Yvonne Hsu-Lin Luo, Lyndon da Cruz |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Visual acuity Visual perception genetic structures Retinal implant Visual Acuity Electric Stimulation Therapy Audiology Blindness Prosthesis Design 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Retinal Diseases Retinitis pigmentosa medicine Animals Humans Retina business.industry Retinal medicine.disease eye diseases Sensory Systems Electrodes Implanted Visual Prosthesis Ophthalmology medicine.anatomical_structure Implantable Neurostimulators chemistry Visual prosthesis 030221 ophthalmology & optometry Optic nerve Visual Perception Optometry medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | Progress in retinal and eye research. 50 |
| ISSN: | 1873-1635 |
| Popis: | The Argus(®) II Retinal Prosthesis System (Second Sight Medical Products) is the first prosthetic vision device to obtain regulatory approval in both Europe and the USA. As such it has entered the commercial market as a treatment for patients with profound vision loss from end-stage outer retinal disease, predominantly retinitis pigmentosa. To date, over 100 devices have been implanted worldwide, representing the largest group of patients currently treated with visual prostheses. The system works by direct stimulation of the relatively preserved inner retina via epiretinal microelectrodes, thereby replacing the function of the degenerated photoreceptors. Visual information from a glasses-mounted video camera is converted to a pixelated image by an external processor, before being transmitted to the microelectrode array at the macula. Elicited retinal responses are then relayed via the normal optic nerve to the cortex for interpretation. We reviewed the animal and human studies that led to the development of the Argus(®) II device. A sufficiently robust safety profile was demonstrated in the phase I/II clinical trial of 30 patients. Improvement of function in terms of orientation and mobility, target localisation, shape and object recognition, and reading of letters and short unrehearsed words have also been shown. There remains a wide variability in the functional outcomes amongst the patients and the factors contributing to these performance differences are still unclear. Future developments in terms of both software and hardware aimed at improving visual function have been proposed. Further experience in clinical outcomes is being acquired due to increasing implantation. |
| Databáze: | OpenAIRE |
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