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Nasibullin B. A., Gushcha S. G., Аrabadji М. V., Stepanova V. S. Features of the reaction of the kidney function of healthy rats to the intake of boric hydrocarbonate sodium mineral waters of varying quantitative macro- and micro-composition. Journal of Education, Health and Sport. 2022;12(6):353-364. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2022.12.06.035 https://apcz.umk.pl/JEHS/article/view/JEHS.2022.12.06.034 https://zenodo.org/record/6948256 The journal has had 40 points in Ministry of Education and Science of Poland parametric evaluation. Annex to the announcement of the Minister of Education and Science of December 1, 2021. No. 32343. Has a Journal's Unique Identifier: 201159. Scientific disciplines assigned: Physical Culture Sciences (Field of Medical sciences and health sciences); Health Sciences (Field of Medical Sciences and Health Sciences). Punkty Ministerialne z 2019 - aktualny rok 40 punktów. Załącznik do komunikatu Ministra Edukacji i Nauki z dnia 1 grudnia 2021 r. Lp. 32343. Posiada Unikatowy Identyfikator Czasopisma: 201159. Przypisane dyscypliny naukowe:Nauki o kulturze fizycznej (Dziedzina nauk medycznych i nauk o zdrowiu); Nauki o zdrowiu (Dziedzina nauk medycznych i nauk o zdrowiu). © The Authors 2022; This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 16.05.2022. Revised: 31.05.2022. Accepted: 30.06.2022. FEATURES OF THE REACTION OF THE KIDNEY FUNCTION OF HEALTHY RATS TO THE INTAKE OF BORIC HYDROCARBONATE SODIUM MINERAL WATERS OF VARYING QUANTITATIVE MACRO- AND MICRO-COMPOSITION B. A. Nasibullin, S. G. Gushcha, М. V. Аrabadji, V. S. Stepanova State Institution «Ukrainian Research Institute of Medical Rehabilitation and Resort Therapy of the Ministry of Health of Ukraine», Odesa, Ukraine gushchasergey11@gmail.com Nasibullin B. A.: ORCID 0000-0003-3963-2374 АDEF Gushcha S. G.: ORCID 0000-0003-3097-5258 ВЕ Abstract The purpose of the work is a comparative assessment of the effect of boron hydrocarbonate sodium mineral waters with a varying quantitative and qualitative composition of macroelements and with different amounts of a bioactive element on the state of the urinary system of rats. Materials and methods. The work was performed on 81 white rats of the Wistar line of auto bred breeding, weighing 180-200 g. The rats were divided into four groups: group 1 - 21 intact rats served as controls; group 2 - 20 rats treated intragastrically with a soft probe MW "Polyana Ploskivskaya" at a dose of 1% of body weight daily, a course of 7 days; group 3 - 20 rats treated with MW "Polyana Kupel" according to the above method; group 4 - 20 rats treated with MW "Svalyava" according to the above process. Before removing the animals from the experiment, daily urine was collected from them; blood was also taken from the tail vein for biochemical studies. At autopsy, pieces of kidneys were taken for histological and histoenzymological studies (the activity of succinate dehydrogenase and lactate dehydrogenase was determined). Results. The histological studies showed no pathological changes in the kidneys were observed with the use of the studied boron MW. Still, there were structural changes, as well as an increase in the activity of redox enzymes. Changes in kidney function were unidirectional with using any of the investigated MW. Still, they had quantitative differences, which are less related to the amount of boron (in the form of orthoboric acid) in 1 liter of MW and more dependent on the osmolarity of the MW, the qualitative composition of macronutrients, and their ratio. Conclusion. We believe that osmolarity, as an integrated indicator of the state of the macronutrient component of MW, can be used to assess its effect on the structural and functional characteristics of the kidneys. Keywords: boron-containing mineral waters; renal parenchyma; diuresis; excretory function; osmolarity. |
