Murine and Human T-Lymphocyte GATA-3 Factors Mediate Transcription through a cis-Regulatory Element within the Human T-Cell Receptor δ Gene Enhancer
| Autor: | Ko, L J, Yamamoto, M, Leonard, M W, George, K M, Ting, P, Engel, J D |
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| Rok vydání: | 1991 |
| Předmět: |
Transcription
Genetic T-Lymphocytes Molecular Sequence Data Receptors Antigen T-Cell GATA3 Transcription Factor Regulatory Sequences Nucleic Acid Transfection Cell Line Mice Sequence Homology Nucleic Acid Animals Humans Amino Acid Sequence Molecular Biology Gene Library Base Sequence Cell Biology TATA Box Globins DNA-Binding Proteins Enhancer Elements Genetic Multigene Family Trans-Activators Rabbits Oligonucleotide Probes Chickens Research Article Transcription Factors |
| Zdroj: | Molecular and Cellular Biology. 11:2778-2784 |
| ISSN: | 1098-5549 |
| Popis: | A family of transcriptional activators has recently been identified in chickens; these transcriptional activators recognize a common consensus motif (WGATAR) through a conserved C4 zinc finger DNA-binding domain. One of the members of this multigene family, cGATA-3, is most abundantly expressed in the T-lymphocyte cell lineage. Analysis of human and murine GATA-3 factors shows a striking degree of amino acid sequence identity and similar patterns of tissue specificity of expression in these three organisms. The murine and human factors are abundantly expressed in a variety of human and murine T-cell lines and can activate transcription through a tissue-specific GATA-binding site identified within the human T-cell receptor delta gene enhancer. We infer that the murine and human GATA-3 proteins play a central and highly conserved role in vertebrate T-cell-specific transcriptional regulation. |
| Databáze: | OpenAIRE |
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