THE INFLUENCE OF SHORT-TERM FASTING ON SERUM LEPTIN LEVELS, AND SELECTED HORMONAL AND METABOLIC PARAMETERS IN MORBIDLY OBESE AND LEAN FEMALES

Autor:	Martin Haluzík, M. Haluzík, M. Matoulek, Sˇ. Svacˇina, J. Hilgertová, T. Haas
Rok vydání:	2001
Předmět:	Adult Blood Glucose Leptin medicine.medical_specialty Hydrocortisone medicine.medical_treatment Body Mass Index chemistry.chemical_compound Endocrinology Dehydroepiandrosterone sulfate Insulin resistance Internal medicine medicine Humans Insulin skin and connective tissue diseases 3-Hydroxybutyric Acid Dehydroepiandrosterone Sulfate business.industry Dehydroepiandrosterone Fasting General Medicine Middle Aged medicine.disease Obesity Hormones Obesity Morbid chemistry Regression Analysis Female business Body mass index hormones hormone substitutes and hormone antagonists Hormone medicine.drug
Zdroj:	Endocrine Research. 27:251-260
ISSN:	1532-4206 0743-5800
DOI:	10.1081/erc-100107185
Popis:	The aim of our study was to compare the changes of serum leptin levels after 24-h fasting in morbidly obese and lean females and to search for hormonal and metabolic factors responsible for the changes in serum leptin levels. Fourteen morbidly obese and twelve lean females were included in the study. The blood for leptin, insulin, cortisol, blood glucose (BG), beta-OH-butyrate (beta-OH), dehydroepiandrosterone (DHEA) and DHEA-sulphate (DHEA-S) measurements was withdrawn before and after a 24-h fast. Basal body mass index (BMI), serum leptin, insulin and beta-OH levels were significantly higher in the obese compared to the lean group. The 24-h fasting decreased significantly BMI, serum leptin (by 20% in obese vs. 62% in lean subjects), insulin (by 23.3% in obese vs. 23.1% in lean subjects) and increased beta-OH (by 36% in obese vs. 1300% in lean subjects). Basal serum leptin levels correlated positively with BMI in both groups and with insulin levels in the obese group. The multiple regression analysis using delta leptin as dependent and the basal values of the rest of studied parameters as independent variables revealed that in lean subjects serum cortisol together with DHEA-S and BMI accounted for 71% of variations of the change of serum leptin levels (delta leptin = 0.31- 0.0101 cortisol + 0.0012 DHEA-S + 0.37 BMI). In obese subjects the 43.9% of variations of the change of serum leptin levels was explained by BMI together with age and DHEA-S levels (delta leptin = 36.09 + 0.35 BMI - 0.717 age- 0.008 DHEA-S). The drop of serum leptin levels after 24-h starvation is significantly blunted in obese compared to lean subjects. The reason for the difference is probably the insulin resistance possibly further modified by different DHEA-S levels.
Databáze:	OpenAIRE
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