Multiple myeloma in Korea--clinical analysis and treatment results in 61 cases
| Autor: | Seon Yang Park, Noe Kyeong Kim, Du Hyuck Choi, In Mok Heo, Hyojin Kim, Byoung Kook Kim, Yung-Jue Bang, Sang Jae Lee, Mun Ho Lee, Dae Seog Heo |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Melphalan
Adult Male medicine.medical_specialty Adolescent Prednisone Multiple myeloma Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans M2 protocol Bone pain Aged Aged 80 and over Hematology Performance status business.industry Melphalan and prednisone Combination chemotherapy Plasma cell neoplasm Middle Aged medicine.disease Surgery Female Original Article medicine.symptom business medicine.drug |
| Zdroj: | The Korean Journal of Internal Medicine |
| ISSN: | 1226-3303 |
| Popis: | A clinical analysis was made of 61 cases of multiple myeloma diagnosed between January 1976 and June 1984 at Seoul National University Hospital using the criteria of the Southwest Oncology Group. The following observations were made. 1) The major clinical problems at Initial presentation were bone pain(52%), anemia(20 %), renal impairment(11%), and infection(10%). 2) Clinical stages at presentation were stage I, 11%; stage II, 8%; and stage III, 81% of patients. Three(5%) of the patients in stage II and 18(31%) in stage III showed renal impairment with a serum creatinine ≥2.0 mg/dl. 3) Combination chemotherapy produced a response rate of 29% with melphalan and prednisone, and 40% with M2 protocol(among 14 and 20 evaluable patients respectively). Both regimens showed statistically significant survival difference between responders and non-responders(p |
| Databáze: | OpenAIRE |
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