Vitamin D Receptor Is a Sepsis-Susceptibility Gene in Chinese Children
| Autor: | Yuanmei Chen, Danni He, Wenquan Niu, Qi Zhang, Wang Yuanyuan, Lu Xiuxiu, Lipeng Zhang, Li Wei, Li Ning |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
China
Polymorphism Single Nucleotide Risk Assessment Calcitriol receptor MED4 Protein Human Sepsis Clinical Research Humans Medicine Genetic Predisposition to Disease Allele Child Gene Genotyping Genetic Association Studies Genetic association business.industry Haplotype Infant General Medicine Odds ratio medicine.disease Case-Control Studies Child Preschool Immunology Receptors Calcitriol Adult Children business |
| Zdroj: | Medical Science Monitor : International Medical Journal of Experimental and Clinical Research |
| ISSN: | 1643-3750 |
| DOI: | 10.12659/msm.932518 |
| Popis: | BACKGROUND We designed an association study among 267 cases of children with sepsis and 283 healthy controls, by genotyping 9 variants in the VDR gene. MATERIAL AND METHODS This was a hospital-based, case-control, genetic association study. In addition to 3 genetic modes of inheritance, haplotype and interaction analyses were employed to examine the prediction of VDR gene for pediatric sepsis. Effect-size estimates are expressed as odds ratio (OR) and 95% confidence interval (CI). RESULTS Two variants in the VDR gene, rs2107301 and rs2189480, were found to play a leading role in susceptibility to sepsis in children. The mutant homozygotes of rs2107301 (CC) and rs2189480 (CC) were associated with a reduced risk of sepsis compared with the corresponding wild homozygotes (OR: 0.44 and 0.43, 95% CI: 0.21-0.92 and 0.23-0.81, p: 0.03 and 0.009, respectively). The mutations of rs2107301-C and rs2189480-C alleles were associated with reduced sepsis risk. Haplotype C-C-C-C-C-T-C-A-G in the VDR gene was significantly associated with a 0.59-fold decreased risk of sepsis (95% CI: 0.12-0.76, p: 0.02). In the haplotype-phenotype analysis, significant association was noted for high-density lipoprotein, even after simulation correction (psim |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|