Dementia prevalence and incidence in a federation of European Electronic Health Record databases: The European Medical Informatics Framework resource

Autor: Johan van der Lei, Robert Stewart, Gayan Perera, Mark Forrest Gordon, Miguel Angel Mayer, Myriam Alexander, Pieter Jelle Visser, Nadia Foskett, Usha Gungabissoon, Rosa Gini, Gerald Novak, Gianluca Trifirò, H. Michael Arrighi, Peter R. Rijnbeek, Paul Avillach, David Ansel, Lars Pedersen
Přispěvatelé: RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, Psychiatrie & Neuropsychologie, Medical Informatics, Amsterdam Neuroscience - Neurodegeneration, Neurology
Rok vydání: 2016
Předmět:
Male
Time Factors
Databases
Factual
Epidemiology
computer.software_genre
Health informatics
0302 clinical medicine
Catchment Area
Health
Reference Values
Demència -- Europa
Prevalence
Medicine
Electronic Health Records
030212 general & internal medicine
RISK
Aged
80 and over
Database
Health Policy
Incidence (epidemiology)
Incidence
Age Factors
EDUCATION
Middle Aged
3. Good health
ALZHEIMERS-DISEASE
Europe
Psychiatry and Mental health
Cohort
SURVIVAL
Female
Diagnosis code
European Medical Informatics Framework
Secondary care
03 medical and health sciences
Cellular and Molecular Neuroscience
AGE
Age Distribution
Developmental Neuroscience
Electronic health record
Dementia
Humans
COHORT
VASCULAR DEMENTIA
Vascular dementia
Aged
Retrospective Studies
business.industry
CARE
medicine.disease
Dementia
Incidence
Prevalence
Electronic Health Records
European Medical Informatics Framework
Neurology (clinical)
Geriatrics and Gerontology
business
computer
030217 neurology & neurosurgery
Medical Informatics
Zdroj: Perera, G, Pedersen, L, Ansel, D, Alexander, M, Arrighi, H M, Avillach, P, Foskett, N, Gini, R, Gordon, M F, Gungabissoon, U, Mayer, M A, Novak, G, Rijnbeek, P, Trifirò, G, van der Lei, J, Visser, P J & Stewart, R 2018, ' Dementia prevalence and incidence in a federation of European Electronic Health Record databases : The European Medical Informatics Framework resource ', Alzheimer's and Dementia, vol. 14, no. 2, pp. 130-139 . https://doi.org/10.1016/j.jalz.2017.06.2270
Alzheimer's & Dementia, 14(2), 130-139. Elsevier Science
Alzheimers & Dementia, 14(2), 130-139. Elsevier Inc.
Perera, G, Pedersen, L, Ansel, D, Alexander, M, Arrighi, H M, Avillach, P, Foskett, N, Gini, R, Gordon, M F, Gungabissoon, U, Mayer, M-A, Novak, G, Rijnbeek, P, Trifirò, G, van der Lei, J, Visser, P J & Stewart, R 2017, ' Dementia prevalence and incidence in a federation of European Electronic Health Record databases : The European Medical Informatics Framework resource ', Alzheimer's & Dementia, pp. 1-10 . https://doi.org/10.1016/j.jalz.2017.06.2270
Perera, G, Pedersen, L, Ansel, D, Alexander, M, Arrighi, H M, Avillach, P, Foskett, N, Gini, R, Gordon, M F, Gungabissoon, U, Mayer, M A, Novak, G, Rijnbeek, P, Trifirò, G, van der Lei, J, Visser, P J & Stewart, R 2018, ' Dementia prevalence and incidence in a federation of European Electronic Health Record databases: The European Medical Informatics Framework resource ', Alzheimer's and Dementia, vol. 14, no. 2, pp. 130-139 . https://doi.org/10.1016/j.jalz.2017.06.2270
Alzheimer's and Dementia, 14(2), 130-139. Elsevier
Recercat. Dipósit de la Recerca de Catalunya
instname
ISSN: 1552-5279
1552-5260
DOI: 10.1016/j.jalz.2017.06.2270
Popis: INTRODUCTION: The European Medical Information Framework consortium has assembled electronic health record (EHR) databases for dementia research. We calculated dementia prevalence and incidence in 25 million persons from 2004 to 2012. METHODS: Six EHR databases (three primary care and three secondary care) from five countries were interrogated. Dementia was ascertained by consensus harmonization of clinical/diagnostic codes. Annual period prevalences and incidences by age and gender were calculated and meta-analyzed. RESULTS: The six databases contained 138,625 dementia cases. Age-specific prevalences were around 30% of published estimates from community samples and incidences were around 50%. Pooled prevalences had increased from 2004 to 2012 in all age groups but pooled incidences only after age 75 years. Associations with age and gender were stable over time. DISCUSSION: The European Medical Information Framework initiative supports EHR data on unprecedented number of people with dementia. Age-specific prevalences and incidences mirror estimates from community samples in pattern at levels that are lower but increasing over time. The research leading to these results has received support from the Innovative Medicines Initiative Joint Undertaking under European Medical Informatics Framework (EMIF) grant agreement no. 115372, resources of which are composed of financial contribution from the European Union’s Seventh Framework Programme (FP7/2007-2013) and European Federation of Pharmaceutical Industries and Associations (EFPIA) companies’ in kind contribution. R.S. and G.P. are partly funded by the National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King’s College London.
Databáze: OpenAIRE
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