Neuromodulation by selective angiotensin-converting enzyme 2 inhibitors

Autor:	Natalia Pozdnyakova, Natalia Krisanova, Artem Pastukhov, Alla Tarasenko, Marina. Dudarenko, Anton Chernykh, Alexander Pashenko, Sergey Ryabukhin, Ganna Tolstanova, Dmitriy Volochnyuk, Tatiana Borisova
Rok vydání:	2022
Předmět:	Neurotransmitter Agents General Neuroscience Imidazoles Presynaptic Terminals Glutamic Acid Rats COVID-19 Drug Treatment Leucine Animals Angiotensin-Converting Enzyme 2 Rats Wistar Reactive Oxygen Species gamma-Aminobutyric Acid Synaptosomes
Zdroj:	Neuroscience. 498
ISSN:	1873-7544
Popis:	Here, neuromodulatory effects of selective angiotensin-converting enzyme 2 (ACE2) inhibitors were investigated. Two different types of small molecule ligands for ACE2 inhibition were selected using chemical genetic approach, they were synthesized using developed chemical method and tested using presynaptic rat brain nerve terminals (synaptosomes). EBC-36032 (1 µM) increased in a dose-dependent manner spontaneous and stimulated ROS generation in nerve terminals that was of non-mitochondrial origin. Another inhibitor EBC-36033 (MLN-4760) was inert regarding modulation of ROS generation. EBC-36032 and EBC-36033 (100 µM) did not modulate the exocytotic release of L-[
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a9188ad0f45d1bbc738d3a803fd52b0 https://pubmed.ncbi.nlm.nih.gov/35817218 Zobrazit plný text záznamu Full Text from ScienceDirect