Comparison of Intrathecal Chemotherapy for Leptomeningeal Carcinomatosis of a Solid Tumor: Methotrexate Alone Versus Methotrexate in Combination with Cytosine Arabinoside and Hydrocortisone
| Autor: | Dae-Young Kim, Tae-You Kim, Yung-Jue Bang, Noe Kyeong Kim, Dong Wan Kim, Tak Yun, Keun Wook Lee, Dae Seog Heo, Jooyoung Jung, Sook Ryun Park |
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| Rok vydání: | 2003 |
| Předmět: |
Adult
Male Oncology Cancer Research medicine.medical_specialty Adolescent Hydrocortisone Adenocarcinoma Gastroenterology Drug Administration Schedule Internal medicine Antineoplastic Combined Chemotherapy Protocols Meningeal Neoplasms medicine Carcinoma Humans Radiology Nuclear Medicine and imaging Carcinoma Small Cell Survival rate Injections Spinal Aged Retrospective Studies business.industry Stomach Cytarabine General Medicine Middle Aged medicine.disease Chemotherapy regimen Survival Rate Methotrexate medicine.anatomical_structure Female business medicine.drug |
| Zdroj: | Japanese Journal of Clinical Oncology. 33:608-612 |
| ISSN: | 1465-3621 |
| Popis: | To compare the efficacy of intrathecal methotrexate single therapy with three-drug combination therapy in patients with leptomeningeal carcinomatosis.Fifty-five patients who had pathologically proven leptomeningeal carcinomatosis of a solid tumor were evaluated in terms of pathological response. Group M (n = 29) received methotrexate 15 mg and group MHA (n = 26) received methotrexate 15 mg, hydrocortisone 15 mg/m(2) and ara-C 30 mg/m(2) twice a week intrathecally until a cytological response was obtained.Primary sites of the tumor were the lung (n = 33), breast (n = 13) and stomach (n = 5). The pathology of 45 patients was adenocarcinoma. The cytological response rate to intrathecal chemotherapy was significantly higher in the MHA group than in the M group (38.5 vs 13.8%, P = 0.036). The median survival was 18.6 weeks in the MHA arm and 10.4 weeks in the M arm (P = 0.029).Combination intrathecal chemotherapy with methotrexate, cytosine arabinoside and hydrocortisone showed more favorable effects than methotrexate single therapy for leptomeningeal carcinomatosis in solid tumors. |
| Databáze: | OpenAIRE |
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