Gold-catalyzed tandem reactions of amide–aldehyde–alkyne coupling and cyclization-synthesis of 2,4,5-trisubstituted oxazoles

Autor:	Nick Uhlig, Pierre Querard, Chao-Jun Li, Simon A. Girard
Rok vydání:	2015
Předmět:	inorganic chemicals chemistry.chemical_classification Tandem Cationic polymerization Alkyne General Chemistry 7. Clean energy Aldehyde Combinatorial chemistry Catalysis Chemistry chemistry.chemical_compound chemistry Amide Side product Organic chemistry
Zdroj:	Chemical Science
ISSN:	2041-6539 2041-6520
Popis:	We report the first cationic gold(i)-catalyzed one-pot reaction of amide, aldehyde and alkyne followed by cyclization, to successfully access highly substituted oxazoles derivatives in good yields. We report the first cationic gold(i)-catalyzed one-pot reaction of amide, alkyne and aldehyde followed by cyclization, to successfully access highly substituted oxazoles derivatives in good yields. A single catalyst allows the occurring of this multi-step reaction atom- and step-economically, with water as the only theoretical side product.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a8ea8c803a437bcc85851cbf0755d1c https://doi.org/10.1039/c5sc02933c Zobrazit plný text záznamu