Endogenous interleukin-10 modulates proinflammatory response in Plasmodium falciparum malaria
| Autor: | Nicholas J. White, Tineke Schollaardt, Sornchai Looareesuwan, May Ho, Susan Snape, Pravan Suntharasamai |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1998 |
| Předmět: |
Adult
Time Factors medicine.medical_treatment Plasmodium falciparum Antigens Protozoan Peripheral blood mononuclear cell Proinflammatory cytokine parasitic diseases medicine Immunology and Allergy Animals Humans Malaria Falciparum Interleukin 6 Cells Cultured biology Interleukin-6 Tumor Necrosis Factor-alpha Interleukin Antibodies Monoclonal biology.organism_classification Interleukin-10 Interleukin 10 Kinetics Infectious Diseases Cytokine Immunology biology.protein Leukocytes Mononuclear Tumor necrosis factor alpha Interleukin-1 |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1537-6613 0022-1899 |
| Popis: | Tumor necrosis factor-a (TNF-a), interleukin (IL)-1b, and IL-6 are implicated in the pathogenesis of severe Plasmodium falciparum malaria. In this study, the effect of IL-10 on their production by peripheral blood mononuclear cells (PBMC) from acutely infected patients was examined. Exogenous IL-10 inhibited malarial antigen ‐ induced cytokine production by reducing mRNA accumulation. Maximal inhibition occurred when IL-10 was added in the firs t2ho fstimulation. Conversely, the addition of anti ‐ IL-10 markedly enhanced TNF-a, IL-1b, and IL-6 production. The effect was significantly greater on PBMC from patients with uncomplicated infection than PBMC from patients with severe disease. Kinetics studies showed that TNF-a, IL-6, and IL-1b were produced within 2 ‐ 4 h of stimulation, while IL-10 was first detectable after 8 h. These findings suggest that IL-10 counter-regulates the proinflammatory response to P. falciparum. Severe falciparum malaria may be associated with an inadequate negative feedback response by IL-10. Severe Plasmodium falciparum infection is associated with multiple steps in the complex sequence of cytokine activation or to use an agent which switches off the whole chain of events. markedly elevated circulating levels of the proinflammatory cytokines tumor necrosis factor (TNF)-a, interleukin (IL)-1b, IL-10 is an 18-kDa peptide, with a number of antiinflammatory and immunosuppressive properties, that is produced by T |
| Databáze: | OpenAIRE |
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