CLINICAL AND EXPERIMENTAL RESEARCH OF IMMUNOMODULATORY EFFECT OF AMISULPRIDE

Autor:	T P Vetlugina, V B Nikitina, Cheĭdo Ma, Idova Gv, Al'perina El, Arkadiy V. Semke, O A Lobacheva, E. N. Zhukova
Rok vydání:	2012
Předmět:	Cellular immunity biology medicine.drug_class business.industry Atypical antipsychotic General Medicine medicine.disease Experimental research Immunity Schizophrenia Immunology Humoral immunity medicine biology.protein Amisulpride Antibody business medicine.drug
Zdroj:	Scopus-Elsevier
ISSN:	2414-3545 0869-6047
Popis:	Study of immunomodulatory effect of atypical antipsychotic amisulpride has revealed a positive clinical effect after 6-week therapy of schizophrenic patients regarding both positive and negative symptoms. A decrease in activity of humoral immunity factors (В lymphocytes, immunoglobulins, HLA-DR+-cells) identified among schizophrenic patients in the process of amisulpride therapy can be attributed to a positive effect optimizing the ratio Th1/Th2. Amisulpride when used under experimental conditions produced a suppression of IgM-immune response in mice of the C57BL/6J strain. This effect was more expressed in animals with aggressive behavior pattern.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a8d9e176b63fa5d72f9bf3cdae2597b https://doi.org/10.15690/vramn.v67i12.475 Zobrazit plný text záznamu