Hemophagocytic Lymphohistiocytosis and Bone Marrow Hemophagocytosis: A 5-Year Institutional Experience at a Tertiary Care Hospital
| Autor: | Neerja Vajpayee, Ajeet Gajra, Kriselle Lao, Namita Sharma |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male endocrine system Pediatrics medicine.medical_specialty Adolescent Antineoplastic Agents Lymphohistiocytosis Hemophagocytic Tertiary Care Centers 03 medical and health sciences Young Adult 0302 clinical medicine Bone marrow aspirate Phagocytosis Bone Marrow hemic and lymphatic diseases Neoplasms Biopsy medicine Humans 030212 general & internal medicine Young adult Child Hemophagocytic lymphohistiocytosis medicine.diagnostic_test business.industry Clinical course Infant General Medicine Tertiary care hospital Middle Aged medicine.disease medicine.anatomical_structure 030228 respiratory system Child Preschool Female Bone marrow Hemophagocytosis business |
| Zdroj: | Southern medical journal. 109(10) |
| ISSN: | 1541-8243 |
| Popis: | Objective The purpose of this study was to correlate the significance of bone marrow hemophagocytosis and analyze outcome data in patients with suspected hemophagocytic lymphohistiocytosis (HLH) at a tertiary care hospital during the course of 5 years. Methods The pathology database of State University of New York Upstate Medical University, Syracuse, was searched for the terms "hemophagocytosis," "hemophagocytic syndrome," and "hemophagocytic lymphohistiocytosis" encompassing the period January 2009-December 2014. Bone marrow aspirate and biopsy specimens, along with ancillary laboratory studies, clinical course, and outcome data, were reviewed for each case. Results Of the 23 patients included in our study, HLH was diagnosed in 14 (60.8%). Bone marrow hemophagocytosis (HPC) was seen in a higher proportion of patients (78.5%) who were diagnosed as having HLH; however, 55.5% of the patients who were not diagnosed as having HLH also showed evidence of bone marrow HPC. Patients with malignancy-associated HLH had a markedly worse outcome compared with patients with nonmalignancy-associated HLH. Conclusions Although bone marrow HPC is fairly sensitive, it is not specific to establish a diagnosis of HLH. A high index of clinical suspicion together with early diagnosis and treatment is imperative to improve outcomes in patients suspected of having HLH. |
| Databáze: | OpenAIRE |
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