Moderate dietary weight loss reduces myocardial steatosis in obese and overweight women
| Autor: | Wolfgang Utz, Michael Boschmann, Jens Jordan, Petra Kast, Mario Hermsdorf, Verena Haas, Julius Traber, Friedrich C. Luft, Martin Pofahl, Sven Haufe, Jeanette Schulz-Menger, Stefan Engeli, Jana Böhnke, Susanne Wiesner |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Cardiac function curve medicine.medical_specialty Myocardial steatosis Type 2 diabetes Overweight Body Mass Index Diet Carbohydrate-Restricted chemistry.chemical_compound Weight loss Internal medicine Weight Loss medicine Humans Obesity Prospective Studies Diet Fat-Restricted Triglycerides Triglyceride business.industry Myocardium Middle Aged medicine.disease Endocrinology Adipose Tissue Diabetes Mellitus Type 2 chemistry Population study Female medicine.symptom Cardiology and Cardiovascular Medicine business Follow-Up Studies |
| Zdroj: | International Journal of Cardiology. 167:905-909 |
| ISSN: | 0167-5273 |
| DOI: | 10.1016/j.ijcard.2012.03.104 |
| Popis: | Excessive myocardial triglyceride (MTG) content in obesity and type 2 diabetes is associated with impaired cardiac function. Previous studies suggest that MTG could be mobilized through lifestyle interventions. We assessed influences of moderate dietary weight loss in non diabetic obese and overweight women on MTG content and cardiac function.We selected a subgroup of 38 women from the B-SMART study population. The B-SMART study compared weight loss and associated metabolic and cardiovascular markers with reduced-carbohydrate and reduced-fat hypocaloric diets. Selected subjects had completed a cardiac magnetic resonance (MR) scan including imaging and proton spectroscopy to assess cardiac structure and function as well as MTG content.An average weight reduction of 5.4 ± 4.3 kg at six months was associated with a relative decrease of MTG of 25% (from 0.72 ± 0.29% at baseline to 0.54 ± 0.23% at follow-up, p0.001). The response was similar with carbohydrate and fat restriction. Diastolic function expressed as ratio of peak filling rate in E- and A-Phase (PFRE/PFRA) was unchanged. Reductions of left atrial size (from 21.9 ± 4.0 cm(2) to 20.0 ± 3.7 cm(2), p=0.002), the normalized ratio of PFRE and early diastolic lengthening velocity PLV (from 8.2 ± 2.6 to 7.5 ± 2.5, p0.001) and fat free mass (from 55.1 ± 6.9 kg to 52.7 ± 6.5 kg, p=0.007) reflected altered cardiac volume loading after diet, but did not correlate to MTG content.Moderate dietary weight loss significantly reduced MTG content in women with uncomplicated overweight or obesity. Macronutrient composition of the diet did not significantly affect the extent of MTG reduction. |
| Databáze: | OpenAIRE |
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