Cerebrospinal fluid-intracranial volume ratio measurements in patients with HIV infection: CLASS image analysis technique
| Autor: | Brian Sweeney, Martyn N.J. Paley, Stanton Newman, B.E. Kendall, A M Clews, Wui K. Chong, Iain D. Wilkinson, Margaret A Hall-Craggs, M. J. G. Harrison, J. K. Shepherd |
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| Rok vydání: | 1994 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Atrophy Cerebrospinal fluid Acquired immunodeficiency syndrome (AIDS) Risk Factors HIV Seronegativity Immunopathology HIV Seropositivity Image Processing Computer-Assisted Humans Medicine Radiology Nuclear Medicine and imaging Prospective Studies Prospective cohort study Sida Acquired Immunodeficiency Syndrome medicine.diagnostic_test biology business.industry Brain Magnetic resonance imaging Homosexuality medicine.disease biology.organism_classification Magnetic Resonance Imaging Models Structural Viral disease business Nuclear medicine |
| Zdroj: | Radiology. 190:879-886 |
| ISSN: | 1527-1315 0033-8419 |
| DOI: | 10.1148/radiology.190.3.8115644 |
| Popis: | PURPOSE: To prospectively study the cerebrospinal fluid volume-total intracranial volume ratio (CSF/ICV) in human immunodeficiency virus (HIV)-infected patients at various stages of disease. MATERIALS AND METHODS: A total of 258 volume measurements were obtained with use of a 1.5-T magnetic resonance (MR) imager and the cluster localized automated spherical segmentation technique (which reduces two-dimensional pixel data from dual spin-echo MR images to a one-dimensional histogram) in 69 control subjects and 189 HIV-infected patients. RESULTS: The CSF/ICV was statistically significantly increased in patients with late-stage (Centers for Disease Control and Prevention group IV) acquired immunodeficiency syndrome (AIDS) (0.16 +/- 0.05 [standard deviation]) compared with seronegative control subjects (0.12 +/- 0.03) and patients without symptoms (0.13 +/- 0.03). CONCLUSION: No substantial change in CSF/ICV occurs until development of late-stage AIDS. |
| Databáze: | OpenAIRE |
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