Bariatric surgery for Prader‐Willi syndrome was ineffective in producing sustainable weight loss: Long term results for up to 10 years
| Autor: | Simon Kin Hung Wong, Candice Chuen-Hing Lam, Enders K.W. Ng, Shirley Yuk-Wah Liu |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male 0301 basic medicine congenital hereditary and neonatal diseases and abnormalities medicine.medical_specialty Sleeve gastrectomy Adolescent medicine.medical_treatment Bariatric Surgery 030209 endocrinology & metabolism Comorbidity Anastomosis Body Mass Index Young Adult 03 medical and health sciences 0302 clinical medicine Weight loss Weight Loss medicine Humans Prospective Studies 030109 nutrition & dietetics Nutrition and Dietetics business.industry Health Policy Standard treatment Public Health Environmental and Occupational Health nutritional and metabolic diseases medicine.disease Obesity Surgery Pediatrics Perinatology and Child Health Female Observational study medicine.symptom business Prader-Willi Syndrome Body mass index |
| Zdroj: | Pediatric Obesity. 15 |
| ISSN: | 2047-6310 2047-6302 |
| DOI: | 10.1111/ijpo.12575 |
| Popis: | Background Obesity control in Prader-Willi syndrome (PWS) is notoriously difficult. The role of bariatric surgery in PWS remains controversial as long-term data are lacking. Objectives To evaluate the 10-year outcomes of bariatric surgery in PWS. Methods This was a prospective observational study on PWS patients who received bariatric surgery and multidisciplinary follow-up programmes for obesity control. Outcomes on weight reduction and comorbidity resolution were evaluated. Results Between 2008 and 2013, five PWS patients (two males, mean age 19.2 ± 3.0 years) with body mass index of 47.3 ± 6.9 kg m-2 received sleeve gastrectomy (n = 2), one anastomosis gastric bypass (n = 2), and Roux-en-Y gastric bypass (n = 1) after failing all non-operative weight loss programmes. The median follow-up was 8.4 ± 2.2 years. The best mean percentage of total weight loss (%TWL) was achieved at 2 years (24.7%). %TWL dropped to 23.3% at 3 years, 11.9% at 5 years, 4.1% at 8 years, and 0% at 10 years. Each patient had at least three comorbidities preoperatively, but none of them had resolution of any one of the comorbidities at the last follow-up. Conclusions Bariatric surgery could not produce sustainable long-term weight loss or comorbidity resolution in PWS. This study suggests that bariatric surgery cannot be recommended to PWS patients as a standard treatment. |
| Databáze: | OpenAIRE |
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