Pattern of urinary proteins in experimental diabetes
| Autor: | Terri L. Meinking, J. Phillip Pennell |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
medicine.medical_specialty
Urinary system medicine.medical_treatment Renal function Diabetes Mellitus Experimental Excretion Glycosuria Internal medicine medicine Albuminuria Animals Insulin Proteinuria business.industry Albumin Rats Endocrinology Nephrology Electrophoresis Polyacrylamide Gel Female Pancreatic islet transplantation medicine.symptom business |
| Zdroj: | Kidney International. 21:709-713 |
| ISSN: | 0085-2538 |
| DOI: | 10.1038/ki.1982.86 |
| Popis: | Proteinuria develops rapidly after the induction of experimental diabetes and is the major abnormality of renal function in chronically diabetic rats [1–9]. Proteinuria can be prevented or reversed by metabolically effective pancreatic islet transplantation or insulin treatment [3–6, 9]. Albumin is the protein moiety whose renal excretion has been studied most extensively in diabetic rats [3, 4, 6, 7]. Increases in albumin excretion of small magnitude have been found in both acutely and chronically diabetic rats during poor metabolic control [3, 6, 7], although this has not been a universal observation [4, 8]. Regardless of the absolute level of albuminuria, it appears that albumin comprises a relatively low proportion (5 to 20%) of total urinary protein in diabetic rats [4, 7, 8]. The purpose of this study was to characterize the pattern of proteins appearing in the urine of acutely diabetic rats by polyacrylamide gel electrophoresis (PAGE) and to evaluate how that pattern changes in response to short-term effective insulin therapy. The patterns of urinary proteins in acutely and chronically diabetic rats were compared. In addition, the relative contribution of albumin to total protein excretion was assessed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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