Association of Tumor Necrosis Factor Gene Polymorphisms with Susceptibility to Dilated Cardiomyopathy in a Han Chinese Population
| Autor: | Meili Lv, Lin Zhang, Wen-Liang Fang, Linbo Gao, Xiao-Wei Su, Haibo Luo, Weibo Liang |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Adult
Cardiomyopathy Dilated Male Risk medicine.medical_specialty Genotype medicine.medical_treatment Cardiomyopathy Single-nucleotide polymorphism Biology Polymorphism Single Nucleotide Gastroenterology Asian People Gene Frequency Population Groups Internal medicine Genetics medicine Humans Allele Lymphotoxin-alpha Molecular Biology Aged Aged 80 and over Tumor Necrosis Factor-alpha Dilated cardiomyopathy Cell Biology General Medicine Odds ratio Middle Aged medicine.disease Molecular biology Cytokine Case-Control Studies Female Tumor necrosis factor alpha Disease Susceptibility |
| Zdroj: | DNA and Cell Biology. 29:625-628 |
| ISSN: | 1557-7430 1044-5498 |
| Popis: | Tumor necrosis factor (TNF) is an immunomodulatory cytokine that plays an important role in many inflammatory and autoimmune diseases. We investigated the correlation between single-nucleotide polymorphisms of the TNF gene [i.e., TNF-α (308), TNF-α (857), TNF-α (863), TNF-α (1031), and TNF-ß (+252)] and dilated cardiomyopathy (DCM). A total of 110 DCM patients and 110 control subjects were genotyped using polymerase chain reaction-restriction fragment length polymorphism and DNA-sequencing assay. GA=AA genotypes of TNF-α (308) were significantly associated with increased risk of DCM compared with GG genotype (odds ratio[OR]=1.92; 95% confidence intervals [CI], 1.05-3.52). Similarly, GA=AA of TNF-ß (+252) was significantly associated with increased risk of DCM compared with GG genotype (OR=1.97; 95% CI, 1.14-3.38). Additionally, A allele of TNF-α (-308) and TNF-ß (+252) was associated with a 1.76-fold increased risk of DCM compared with G allele (OR=1.76; 95% CI, 1.05-2.95 and OR=1.79; 95% CI, 1.22-2.63, respectively). However,no association between DCM and TNF-α (857), TNF-α (1031), and TNF-α (863) was observed. TNF gene polymorphisms may be associated with risk of DCM. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|