| Autor: |
Vanobberghen, F., Lweno, O., Kümmerle, A., Mwebi, K. D., Asilia, P., Simon, B., Mswata, S., Schmidlin, S., Glass, T. R., Daubenberger, C., Tanner, M., Meyer-Monard, S. |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Popis: |
Background: Iron deficiency anaemia is of major concern in low-income settings, especially for women of childbearing age. Oral iron substitution efficacy is limited by poor compliance and iron depletion severity. We aimed to assess the efficacy and safety of intravenous ferric carboxymaltose versus oral iron substitution following childbirth in women with iron deficiency anaemia in Tanzania. Methods: This parallel-group, open-label, randomised controlled phase 3 trial was done at Bagamoyo District Hospital and Mwananyamala Hospital, Tanzania. Eligible participants were close to delivery and had iron deficiency anaemia defined as a haemoglobin concentration of less than 110 g/L and a ferritin concentration of less than 50 μg/L measured within 14 days before childbirth. Participants were randomly assigned 1:1 to receive intravenous ferric carboxymaltose or oral iron, stratified by haemoglobin concentration and site. Intravenous ferric carboxymaltose was administered at a dose determined by the haemoglobin concentration and bodyweight (bodyweight 35 kg to |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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