Active propagation of dendritic electrical signals in C. elegans
| Autor: | Mayumi Ochi-Shindou, Jeffery R. Wickens, Yuto Momohara, Tomomi Shindou, Ei-ichiro Saita, Ichiro N. Maruyama, Takashi Murayama |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Patch-Clamp Techniques Sensory Receptor Cells lcsh:Medicine Action Potentials Sensory system Article Membrane Potentials 03 medical and health sciences 0302 clinical medicine medicine Animals Patch clamp Calcium Signaling lcsh:Science Caenorhabditis elegans Ion channel Calcium signaling Membrane potential Multidisciplinary Chemistry lcsh:R Depolarization Chemotaxis Dendrites Sensory neuron Electrophysiological Phenomena 030104 developmental biology medicine.anatomical_structure Biophysics lcsh:Q Calcium 030217 neurology & neurosurgery |
| Zdroj: | Scientific Reports Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019) |
| ISSN: | 2045-2322 |
| Popis: | Active propagation of electrical signals in C. elegans neurons requires ion channels capable of regenerating membrane potentials. Here we report regenerative depolarization of a major gustatory sensory neuron, ASEL. Whole-cell patch-clamp recordings in vivo showed supralinear depolarization of ASEL upon current injection. Furthermore, stimulation of animal’s nose with NaCl evoked all-or-none membrane depolarization in ASEL. Mutant analysis showed that EGL-19, the α1 subunit of L-type voltage-gated Ca2+ channels, is essential for regenerative depolarization of ASEL. ASEL-specific knock-down of EGL-19 by RNAi demonstrated that EGL-19 functions in C. elegans chemotaxis along an NaCl gradient. These results demonstrate that a natural substance induces regenerative all-or-none electrical signals in dendrites, and that these signals are essential for activation of sensory neurons for chemotaxis. As in other vertebrate and invertebrate nervous systems, active information processing in dendrites occurs in C. elegans, and is necessary for adaptive behavior. |
| Databáze: | OpenAIRE |
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