Cladobotric Acids: Metabolites from Cultures of Cladobotryum sp., Semisynthetic Analogues and Antibacterial Activity

Autor:	Trong-Tuan Dao, Katherine Williams, Kate M. J. de Mattos-Shipley, Zhongshu Song, Yuiko Takebayashi, Thomas J. Simpson, James Spencer, Andrew M. Bailey, Christine L. Willis
Rok vydání:	2022
Předmět:	Pharmacology Complementary and alternative medicine Organic Chemistry Drug Discovery Pharmaceutical Science Molecular Medicine biochemical phenomena metabolism and nutrition Analytical Chemistry
Zdroj:	Dao, T T, Williams, K, de Mattos-Shipley, K M J, Song, Z, Takebayashi, Y, Simpson, T J, Spencer, J, Bailey, A M & Willis, C L 2022, ' Cladobotric acids: Metabolites from cultures of Cladobotryum sp., semi-synthetic analogues and antibacterial activity ', Journal of Natural Products, vol. 85, no. 3, pp. 572-580 . https://doi.org/10.1021/acs.jnatprod.1c01063
ISSN:	1520-6025 0163-3864
Popis:	Three new polyketide-derived natural products, cladobotric acids G–I (1–3), and six known metabolites (4, 5, 8–11) were isolated from fermentation of the fungus Cladobotryum sp. grown on rice. Their structures were elucidated by extensive spectroscopic methods. Two metabolites, cladobotric acid A (4) and pyrenulic acid A (10), were converted to a series of new products (12–20) by semisynthesis. The antibacterial activities of all these compounds were investigated against the Gram-positive pathogen Staphylococcus aureus including methicillin-susceptible (MSSA), methicillin-resistant and vancomycin-intermediate (MRSA/VISA), and heterogeneous vancomycin-intermediate (hVISA) strains. Results of these antibacterial assays revealed structural features of the unsaturated decalins important for biological activity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a7e5b2521ebfde65846ed25cb388880 https://doi.org/10.1021/acs.jnatprod.1c01063 Zobrazit plný text záznamu