Micronutrient deficiencies are common in 6- to 8-year-old children of rural Nepal, with prevalence estimates modestly affected by inflammation
| Autor: | Hongjie Cui, Kerry Schulze, Lee S.F. Wu, Christine P. Stewart, Margia Arguello, Subarna K. Khatry, Steven C. LeClerq, Ashika Nanayakkara-Bind, Keith P. West, Parul Christian |
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| Rok vydání: | 2014 |
| Předmět: |
Rural Population
Male Cross-sectional study alpha-Tocopherol Medicine (miscellaneous) Physiology chemistry.chemical_compound Hemoglobins Receptors Prevalence Medicine Micronutrients Vitamin D Vitamin A Child Subclinical infection education.field_of_study Nutrition and Dietetics Transferrin Anemia Micronutrient C-Reactive Protein Female Population Nutritional Status Folic Acid Deficiency Cobalamin Selenium Food Sciences Nepal Animal Production Humans education Inflammation Nutrition & Dietetics business.industry Iron-Deficiency medicine.disease Malnutrition Logistic Models Cross-Sectional Studies chemistry Socioeconomic Factors Immunology Dietary Supplements Ferritins business Copper deficiency Copper |
| Zdroj: | The Journal of nutrition, vol 144, iss 6 Schulze, KJ; Christian, P; Wu, LSF; Arguello, M; Cui, H; Nanayakkara-Bind, A; et al.(2014). Micronutrient deficiencies are common in 6-to 8-year-old children of rural Nepal, with prevalence estimates modestly affected by inflammation. Journal of Nutrition, 144(6), 979-987. doi: 10.3945/jn.114.192336. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/9cx2v2rh |
| Popis: | Subclinical micronutrient deficiencies remain a hidden aspect of malnutrition for which comprehensive data are lacking in school-aged children. We assessed the micronutrient status of Nepalese children, aged 6 to 8 y, born to mothers who participated in a community-based antenatal micronutrient supplementation trial from 1999 to 2001. Of 3305 participants, plasma indicators were assessed in a random sample of 1000 children. Results revealed deficiencies of vitamins A (retinol 2 μg/L, 20%), B-12 (cobalamin 8.3 mg/L, 40.1%; TfR:ferritin >500 μg/μg, 14.3%], iodine (thyroglobulin >40 μg/L, 11.4%), and selenium (plasma selenium 1 g/L, C-reactive protein >5 mg/L, or both) was present in 31.6% of children, affecting the prevalence of deficiency as assessed by retinol, β-carotene, PLP, ferritin, TfR, selenium, copper, or having any or multiple deficiencies. For any nutrient, population deficiency prevalence estimates were altered by ≤5.4% by the presence of inflammation, suggesting that the majority of deficiencies exist regardless of inflammation. Multiple micronutrient deficiencies coexist in school-aged children in rural Nepal, meriting more comprehensive strategies for their assessment and prevention. |
| Databáze: | OpenAIRE |
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