Polymer gel dosimetry for synchrotron stereotactic radiotherapy and iodine dose-enhancement measurements
| Autor: | Julia Rousseau, Hélène Elleaume, François Estève, Irène Troprès, Jean-François Adam, Caroline Boudou, Laurent Lamalle |
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| Přispěvatelé: | Grenoble Institut des Neurosciences (GIN), Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM), European Synchrotron Radiation Facility (ESRF), Université Joseph Fourier - Grenoble 1 (UJF), Service d'Imagerie par Résonance Magnétique (IRM), CHU Grenoble, Serduc, Raphael |
| Rok vydání: | 2007 |
| Předmět: |
Materials science
MESH: Iodine Polymers MESH: Gels chemistry.chemical_element Dose profile Radiation Gel dosimetry Iodine Radiosurgery Sensitivity and Specificity Imaging phantom 030218 nuclear medicine & medical imaging law.invention 03 medical and health sciences 0302 clinical medicine law MESH: Radiosurgery MESH: Dose-Response Relationship Radiation Dosimetry Radiology Nuclear Medicine and imaging [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Irradiation MESH: Radiotherapy Dosage Radiometry Radiological and Ultrasound Technology business.industry Radiochemistry MESH: Radiometry Reproducibility of Results Dose-Response Relationship Radiation Radiotherapy Dosage Synchrotron MESH: Sensitivity and Specificity MESH: Polymers MESH: Reproducibility of Results chemistry 030220 oncology & carcinogenesis MESH: Synchrotrons [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Nuclear medicine business Gels Synchrotrons |
| Zdroj: | Physics in Medicine and Biology Physics in Medicine and Biology, IOP Publishing, 2007, 52 (16), pp.4881-92. ⟨10.1088/0031-9155/52/16/011⟩ |
| ISSN: | 0031-9155 1361-6560 |
| DOI: | 10.1088/0031-9155/52/16/011⟩ |
| Popis: | International audience; Synchrotron stereotactic radiotherapy (SSR) is a radiotherapy technique that makes use of the interactions of monochromatic low energy x-rays with high atomic number (Z) elements. An important dose-enhancement can be obtained if the target volume has been loaded with a sufficient amount of a high-Z element, such as iodine. In this study, we compare experimental dose measurements, obtained with normoxic polymer gel (nPAG), with Monte Carlo computations. Gels were irradiated within an anthropomorphic head phantom and were read out by magnetic resonance imaging. The dose-enhancement due to the presence of iodine in the gel (iodine concentration: 5 and 10 mg ml(-1)) was measured at two radiation energies (35 and 80 keV) and was compared to the calculated factors. nPAG dosimetry was shown to be efficient for measuring the sharp dose gradients produced by SSR. The agreement between 3D gel dosimetry and calculated dose distributions was found to be within 4% of the dose difference criterion and a distance to agreement of 2.1 mm for 80% of the voxels. Polymer gel doped with iodine exhibited higher sensitivity, in good agreement with the calculated iodine-dose enhancement. We demonstrate in this preliminary study that iodine-doped nPAG could be used for measuring in situ dose distributions for iodine-enhanced SSR treatment. |
| Databáze: | OpenAIRE |
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