Plasma IL-8 and ICOSLG as prognostic biomarkers in glioblastoma
| Autor: | Ib Jarle Christensen, Camilla Bjørnbak Holst, Petra Hamerlik, Jane Skjøth-Rasmussen, Kristoffer Vitting-Seerup, Hans Skovgaard Poulsen, Julia S. Johansen |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
IL-8 business.industry Clinical Investigations glioblastoma Brain tumor circulating biomarkers Astrocytoma medicine.disease ICOS LIGAND 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Immune system Immune privilege 030220 oncology & carcinogenesis Glioma ICOS ligand medicine Cancer research AcademicSubjects/MED00300 Biomarker (medicine) AcademicSubjects/MED00310 Interleukin 8 business |
| Zdroj: | Holst, C B, Christensen, I J, Vitting-Seerup, K, Skjøth-Rasmussen, J, Hamerlik, P, Poulsen, H S & Johansen, J S 2021, ' Plasma IL-8 and ICOSLG as prognostic biomarkers in glioblastoma ', Neuro-Oncology Advances, vol. 3, no. 1 . https://doi.org/10.1093/noajnl/vdab072 Neuro-oncology Advances |
| ISSN: | 2632-2498 |
| Popis: | Background CNS immune privilege has been challenged in recent years. Glioblastoma (GBM) immune dysfunction includes complex interactions with the immune system outside the CNS. The aim of this study was to determine diagnostic and prognostic potential of immune-related proteins in plasma in GBM and interrogate biomarker presence in the brain tumor microenvironment (TME). Methods One hundred and fifty-eight patients with glioma WHO grade II–IV were included. Plasma collected at surgery was screened for 92 proteins using proximity extension assay technology and related to clinical outcome. Secretion and expression of candidate prognostic biomarkers were subsequently analyzed in 8 GBM cell lines and public RNAseq data. Results Plasma levels of 20 out of 92 screened proteins were significantly different in patients with GBM compared to patients with astrocytoma WHO grade II–III. High plasma interleukin-8 (IL-8) (hazard ratio [HR] = 1.52; P = .0077) and low CD244 (HR = 0.36; P = .0004) were associated with short progression-free survival and high plasma IL-8 (HR = 1.40; P = .044) and low ICOS ligand (ICOSLG) (HR = 0.17; P = .0003) were associated with short overall survival (OS) in newly diagnosed patients with GBM. A similar trend was found for ICOSLG (HR = 0.34; P = .053) in recurrent GBM. IL-8 was mostly secreted and expressed by mesenchymal GBM cell lines and expressed by vascular cells and immune cells in the TME. This was also the case for ICOSLG, although less consistent, and with additional expression in tumor-associated oligodendrocytes. Conclusions High plasma IL-8 and low ICOSLG at surgery are associated with short OS in newly diagnosed GBM. Source of plasma ICOSLG may be found outside the TME. |
| Databáze: | OpenAIRE |
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