Rapid Changes of Prolactinoma Volume after Withdrawal and Reinstitution of Bromocriptine*
| Autor: | Richard L. Perryman, Ivan S. Login, Brian P. Conway, Michael O. Thorner, J. Leon Morris, Robert M. MacLeod, Alan D. Rogol |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Adult
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism Clinical Biochemistry Biochemistry Drug withdrawal Endocrinology Pituitary mass Internal medicine medicine Humans Pituitary Neoplasms In patient Radionuclide Imaging Bitemporal hemianopsia Bromocriptine Prolactinoma Tumor size business.industry Size reduction Biochemistry (medical) medicine.disease Prolactin business medicine.drug |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 53:480-483 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jcem-53-3-480 |
| Popis: | Medical therapy of prolactinomas with bromo-criptine has been demonstrated to reduce serum PRL levels to normal and also to reduce the size of such tumors. This size reduction may occur very rapidly. It is widely recognized that PRL levels rise again after withdrawal of bromocriptine therapy. We now describe the effects of drug withdrawal and reinstitution on tumor size in two young men harboring large prolactinomas. Bromocriptine had been extremely successful in lowering serum PRL levels by more than 80%, as well as reducing tumor size. After 12 months of therapy bromocriptine was withdrawn. Within 48 h PRL levels had started to rise, reaching 2580 ng/ml at 13 days off therapy and 1040 ng/ml at 4 weeks off therapy in patients 1 and 2, respectively. At 13 days bitemporal hemianopsia recurred in patient 1, and this was associated with radiographic demonstration of expansion in the pituitary mass from a partially empty pituitary fossa to a large 12-mm suprasellar extension. The second patient remained asymp... |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|