Asymmetry in cortical thickness and subcortical volume in treatment-naïve major depressive disorder
| Autor: | Chang Li, Qianying Tang, Haitao Li, Qi Han, Yao Wang, Wei Qu, Zhiwei Zuo, Shuhua Ran |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
MDD major depressive disorder lcsh:RC346-429 Functional Laterality 0302 clinical medicine GLM general linear model Brain asymmetry Asymmetry Index Cerebral Cortex SDS Self-rating Depression Scale 05 social sciences Brain Magnetic Resonance Imaging Neurology DLPFC dorsolateral prefrontal cortex lcsh:R858-859.7 Major depressive disorder Female MRI SAS Self-rating Anxiety Scale AI asymmetry index Adult Cognitive Neuroscience Thalamus Nucleus accumbens lcsh:Computer applications to medicine. Medical informatics 050105 experimental psychology Lateralization of brain function Article Cortical thickness 03 medical and health sciences VBM voxel-based morphometry Neuroimaging medicine Humans 0501 psychology and cognitive sciences Radiology Nuclear Medicine and imaging lcsh:Neurology. Diseases of the nervous system Subcortical volume Depressive Disorder Major HAM-D24 24-item Hamilton Depression Scale business.industry Asymmetry medicine.disease Neurology (clinical) Hypoactivity business Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | NeuroImage : Clinical NeuroImage: Clinical, Vol 21, Iss, Pp-(2019) |
| ISSN: | 2213-1582 |
| Popis: | Background Numerous cognitive and emotional functions are executed asymmetrically between the left and right hemispheres. Right hemisphere hyperactivity/left hemisphere hypoactivity often appears to be a feature in neuroimaging studies of depression. However, few studies have evaluated abnormalities in structural asymmetry in untreated patients with major depressive disorder (MDD). Methods In this study, 3-dimensional high-resolution structural magnetic resonance images were acquired from 35 treatment-naïve patients with MDD (mean age = 28.9 years, 22 females) and 35 normal controls. The asymmetry index in cortical thickness and subcortical volume were calculated based on an automated surface-based technique. Results Abnormalities in structural asymmetry in patients with MDD were mainly located in the cortical-striatal-pallidal-thalamic circuit, including the superior frontal cortex, rostral middle frontal cortex, caudal middle frontal cortex, nucleus accumbens, pallidum and thalamus. No significant correlation was observed between symptom severity and asymmetric measurements. Conclusion These findings provide further evidence for the altered morphological interhemispheric imbalances in depression and these alterations were independent of depressive symptom severity, suggesting that cerebral asymmetry could be an appropriate indicator of morphological variations in mental disease. Highlights • Cortical asymmetric changes in depression mainly involved the frontal cortex. • Clinical variables were not associated with cerebral asymmetry. • Cerebral asymmetry could be an indicator of morphological variations in depression. |
| Databáze: | OpenAIRE |
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