Influence of Biosynthetic Human Growth Hormone on the Biomechanical Strength Development in Skin Incisional Wounds of Diabetic Rats
| Autor: | H. Oxlund, Mikkel Seyer-Hansen, T.T. Andreassen, P.H. Jørgensen |
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| Rok vydání: | 1993 |
| Předmět: |
Blood Glucose
medicine.medical_specialty Skin wound Body weight Diabetes Mellitus Experimental Diabetes mellitus Internal medicine Mechanical strength medicine Animals Rats Wistar Skin Wound Healing integumentary system business.industry Body Weight Biomechanical strength medicine.disease Biomechanical Phenomena Rats Endocrinology Growth Hormone Female Surgery Biosynthetic human growth hormone business Wound healing hormones hormone substitutes and hormone antagonists Hormone |
| Zdroj: | European Surgical Research. 25:162-168 |
| ISSN: | 1421-9921 0014-312X |
| Popis: | The influence of biosynthetic human growth hormone (b-hGH) on the mechanical strength development of skin incisional wounds in diabetic rats has been investigated after 4, 7 and 21 days of healing. Diabetes caused decreased mechanical strength of the wounds. After 21 days of healing, the diabetic animals treated with b-hGH from 7 days before wound infliction had an increased maximum load (14%) compared with the untreated diabetic animals. After 4 and 7 days of healing, no differences in the biomechanical strength of diabetic wounds with and without b-hGH treatment were found. The diabetic animals receiving b-hGH showed a significant increase in body weight compared with the untreated diabetic animals. In the diabetic animals, the blood glucose concentration was increased by treatment with b-hGH. In conclusion, treatment with b-hGH from 7 days before operation can counteract the reduced mechanical strength of skin wounds in diabetic rats on day 21. |
| Databáze: | OpenAIRE |
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