A genetic variant of the atrial natriuretic peptide gene is associated with cardiometabolic protection in the general community
| Autor: | John C. Burnett, Maurizio Averna, Kent R. Bailey, Timothy M. Olson, Guido Boerrigter, Paul M. McKie, Lisa C. Costello-Boerrigter, Denise M. Heublein, Alessandro Cataliotti, Brian D. Lahr, Margaret M. Redfield, Valentina Cannone, Richard J. Rodeheffer |
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| Přispěvatelé: | Cannone V, Boerrigter G, Cataliotti A, Costello-Boerrigter LC, Olson TM, McKie PM, Heublein DM, Lahr BD, Bailey KR, Averna M, Redfield MM, Rodeheffer RJ, Burnett JC Jr |
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty Linkage disequilibrium Settore MED/09 - Medicina Interna Genotype medicine.drug_class Population Blood Pressure Article metabolic syndrome Body Mass Index Random Allocation Atrial natriuretic peptide Internal medicine atrial natriuretic peptide lipid metabolism Natriuretic Peptide Brain Homeostasi medicine Natriuretic peptide Homeostasis Humans Allele education Alleles Aged education.field_of_study cardiometabolic disease business.industry Genetic Variation DNA Middle Aged medicine.disease Echocardiography Doppler Genotype frequency Protein Structure Tertiary Minor allele frequency Endocrinology Phenotype Female Metabolic syndrome business Cardiology and Cardiovascular Medicine natriuretic peptides Atrial Natriuretic Factor Human |
| Popis: | Objectives We sought to define the cardiometabolic phenotype associated with rs5068, a genetic variant of the atrial natriuretic peptide (ANP) gene. Background The ANP and B-type natriuretic peptide play an important role in cardiorenal homeostasis but also exert metabolic actions. Methods We genotyped 1,608 randomly selected residents from Olmsted County, Minnesota. Subjects were well-characterized. Results Genotype frequencies were: AA 89.9%, AG 9.7%, and GG 0.4%; all subsequent analyses were AA versus AG+GG. The G allele was associated with increased plasma levels of N-terminal pro-atrial natriuretic peptide (p = 0.002), after adjustment for age and sex. The minor allele was also associated with lower body mass index (BMI) (p = 0.006), prevalence of obesity (p = 0.002), waist circumference (p = 0.021), lower levels of C-reactive protein (p = 0.027), and higher values of high-density lipoprotein cholesterol (p = 0.019). The AG+GG group had a lower systolic blood pressure (p = 0.011) and lower prevalence of myocardial infarction (p = 0.042). The minor allele was associated with a lower prevalence of metabolic syndrome (p = 0.025). The associations between the G allele and high-density lipoprotein cholesterol, C-reactive protein values, myocardial infarction, and metabolic syndrome were not significant, after adjusting for BMI; the associations with systolic blood pressure, BMI, obesity, and waist circumference remained significant even after adjusting for N-terminal pro-atrial natriuretic peptide. Conclusions In a random sample of the general U.S. population, the minor allele of rs5068 is associated with a favorable cardiometabolic profile. These findings suggest that rs5068 or genetic loci in linkage disequilibrium might affect susceptibility for cardiometabolic diseases and support the possible protective role of natriuretic peptides by their favorable effects on metabolic function. Replication studies are needed to confirm our findings. |
| Databáze: | OpenAIRE |
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