Automated measurement of iris surface smoothness using anterior segment optical coherence tomography
| Autor: | Elias Khalili Pour, Hamid Riazi-Esfahani, Mehdi Yaseri, Hossein Arabalibeik, Behnam Mousavi, Tahereh Mahmoudi, Mohammad Zarei, Nazanin Ebrahimiadib |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Iris surface genetic structures Intraclass correlation Science Iris 02 engineering and technology Article Uveitis 03 medical and health sciences 0302 clinical medicine Optical coherence tomography Anterior Eye Segment 0202 electrical engineering electronic engineering information engineering medicine Humans Iris (anatomy) Tomography Aged Multidisciplinary Smoothness (probability theory) medicine.diagnostic_test business.industry Diagnostic markers Middle Aged medicine.disease eye diseases medicine.anatomical_structure Case-Control Studies 030221 ophthalmology & optometry Referral center Medicine Female 020201 artificial intelligence & image processing Medical imaging sense organs Nuclear medicine business Algorithms Tomography Optical Coherence Automated method |
| Zdroj: | Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021) Scientific Reports |
| ISSN: | 2045-2322 |
| Popis: | Fuchs uveitis (FU) is a chronic and often unilateral ocular inflammation and characteristic iris atrophic changes, other than heterochromia, are common in FU and are key to the correct diagnosis in many cases. With the advent of anterior segment optical coherence tomography (AS-OCT), some investigators attempted to quantitatively study these atrophic changes; mostly by introducing various methods to measure iris thickness in AS-OCT images. We aimed to present an automated method in an observational case series to measure the smoothness index (SI) of the iris surface in AS-OCT images. The ratio of the length of the straight line connecting the most peripheral and central points of the anterior iris border (in nasal and temporal sides) to the actual length of this border on AS-OCT images, was defined as SI. In a uveitis referral center, twenty-two eyes of 11 patients with unilateral Fuchs uveitis (FU) (7 female) and 22 eyes of 11 healthy control subjects underwent AS-OCT imaging. Image J and a newly developed MATLAB algorithm were used for manual and automated SI measurements, respectively. Agreement between manual and automated measurements was evaluated with Bland–Altman analysis and interclass correlation coefficient. The inter-eye difference of SI was compared between the FU group and the control group. Automated mean overall SI was 0.868 ± 0.037 and 0.840 ± 0.039 in FU and healthy fellow eyes, respectively (estimated mean difference = − 0.028, 95% CI [− 0.038, − 0.018], p p = 0.01). We concluded that the automated algorithm can rapidly and conveniently measure SI with results comparable to the manual method. |
| Databáze: | OpenAIRE |
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