Early childhood social reticence and neural response to peers in preadolescence predict social anxiety symptoms in midadolescence

Autor:	Adina C. Heckelman, Ellen Leibenluft, Nicholas R. Eaton, Johanna M. Jarcho, Daniel S. Pine, Nathan A. Fox, Eric E. Nelson, Tessa Clarkson, Stefanie L Sequeira
Rok vydání:	2019
Předmět:	Male Article Peer Group 03 medical and health sciences 0302 clinical medicine Neuroimaging medicine Humans Interpersonal Relations Early childhood Risk factor Child Peer interaction Preadolescence medicine.diagnostic_test Social anxiety Brain Phobia Social Fear Magnetic Resonance Imaging 030227 psychiatry Psychiatry and Mental health Clinical Psychology Child Preschool Female Functional magnetic resonance imaging Psychology Insula 030217 neurology & neurosurgery Clinical psychology
Zdroj:	Depress Anxiety
ISSN:	1520-6394 1091-4269
DOI:	10.1002/da.22910
Popis:	Background Early childhood social reticence (SR) and preadolescent social anxiety (SA) symptoms increase the risk for more severe SA in later adolescence. Yet, not all at-risk youth develop more severe SA. The emergence of distinct patterns of neural response to socially evocative contexts during pivotal points in development may help explain this discontinuity. We tested the extent to which brain function during social interactions in preadolescence influenced the effects of SA and early childhood SR on predicting SA symptoms in midadolescence. Methods Participants (N = 53) were assessed for SR from ages 2 to 7. At age 11, SA symptoms were assessed and brain function was measured using functional magnetic resonance imaging (fMRI) as participants anticipated social evaluation from purported peers with a reputation for being unpredictable, nice, and mean. At age 13, SA symptoms were re-assessed. Moderated-mediation models tested the extent to which early childhood SR, preadolescent SA, and preadolescent brain function predicted midadolescent SA. Results In individuals with preadolescent SA, the presence of early childhood SR and SR-linked differences in brain activation predicted more severe SA in midadolescence. Specifically, in those who exhibited preadolescent SA, greater early childhood SR was associated with enhanced bilateral insula engagement while anticipating unpredictable-versus-nice social evaluation in preadolescence, and more severe SA in midadolescence. Conclusions SR-linked neural responses to socially evocative peer interactions may predict more severe SA symptoms in midadolescence among individuals with greater preadolescent SA symptoms and childhood SR. This same pattern of neural response may not be associated with more severe SA symptoms in youth with only one risk factor.
Databáze:	OpenAIRE
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