Antimicrobial susceptibility surveillance of bacterial isolates recovered in Japan from odontogenic infections in 2013
| Autor: | Tetsuo Oonishi, Tsuyoshi Takato, Hiroshi Kiyota, Daisuke Miyai, Ryo Akasiba, Yoshinori Jinbu, Reiko Kato, Tomotaro Wakamura, Hiromitsu Kishimoto, Mikio Kusama, Kazumi Izawa, Haruo Sakamoto, Soichi Iwai, Takashi Yoshii, Koichi Matsumoto, Yoshiro Matsui, Taku Kanda, Tetsuya Matsumoto, Hideaki Hanaki, Minoru Miyake, Nobuo Yamane, Shungo Furudoi, Noriyuki Sakakibara, Hideki Tanzawa, Akihiro Kaneko, Hiroyuki Naito, Kenichiro Hashimoto, Norito Miyagi, Tetsuro Ikebe, Tetsuji Okamoto, Masahiro Urade, Akihiko Sakamoto, Takayuki Mizuno, Shosuke Morita, Jiro Sasaki, Fumitaka Terasawa, Ritsuo Takagi, Hideki Watanabe, Takefumi Morihana, Takahiko Shibahara, Takashi Sawai, Hiroyuki Kubota, Atsuo Kaetsu, Masashi Sasaki, Takahide Komori, Yasumitsu Kodama, Hisashi Miyajima, Yasunobu Busujima, Akira Yamaguchi, Kazuhiro Matsumoto, Yoshinao Kozu, Masataka Uematsu, Junko Sato, Noriko Nakatogawa, Kazuhiro Tateda, Hiroshi Iwabuchi, Yoshiaki Yura, Junko Fujibayashi, Daisuke Watanabe, Kosei Okamoto |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Microbiology (medical) 030106 microbiology Drug resistance Microbial Sensitivity Tests Penicillins Biology medicine.disease_cause Microbiology 03 medical and health sciences Bacteria Anaerobic 0302 clinical medicine Japan Drug Resistance Bacterial medicine Prevotella Humans Pharmacology (medical) 030212 general & internal medicine Odontogenic infection Streptococcus Clindamycin Bacterial Infections medicine.disease Antimicrobial biology.organism_classification Anti-Bacterial Agents Infectious Diseases Fusobacterium Anaerobic bacteria medicine.drug |
| Zdroj: | Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy. 26(9) |
| ISSN: | 1437-7780 |
| Popis: | We report on the findings of the first antimicrobial susceptibility surveillance study in Japan of isolates recovered from odontogenic infections. Of the 38 facilities where patients representing the 4 groups of odontogenic infections were seen, 102 samples were collected from cases of periodontitis (group 1), 6 samples from pericoronitis (group 2), 84 samples from jaw inflammation (group 3) and 54 samples from phlegmon of the jaw bone area (group 4) for a total of 246 samples. The positivity rates of bacterial growth on culture were 85.3%, 100%, 84% and 88.9%, respectively, for groups 1, 2, 3 and 4. Streptococcus spp. isolation rates according to odontogenic infection group were 22% (group 1), 17.7% (group 3) and 20.7% (group 4). Anaerobic isolation rates were 66.9% (group 1), 71.8% (group 3) and 68.2% (group 4). Drug susceptibility tests were performed on 726 strains excluding 121 strains that were undergrown. The breakdown of the strains subjected to testing was 186 Streptococcus spp., 179 anaerobic gram-positive cocci, 246 Prevotella spp., 27 Porphyromonas spp., and 88 Fusobacterium spp. The isolates were tested against 30 antimicrobial agents. Sensitivities to penicillins and cephems were good except for Prevotella spp. The low sensitivities of Prevotella spp is due to β-lactamase production. Prevotella strains resistant to macrolides, quinolones, and clindamycin were found. No strains resistant to carbapenems or penems were found among all strains tested. No anaerobic bacterial strain was resistant to metronidazole. Antimicrobial susceptibility testing performed on the S. anginosus group and anaerobic bacteria, which are the major pathogens associated with odontogenic infections, showed low MIC90 values to the penicillins which are the first-line antimicrobial agents for odontogenic infections; however, for Prevotella spp., penicillins combined with β-lactamase inhibitor showed low MIC90 values. |
| Databáze: | OpenAIRE |
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