Comparison of the effects of meloxicam and dexketoprofen on postoperative adhesion formation in a rat uterine horn surgical model
| Autor: | S. Mehmet Akkus, Hikmet Keleş, Tayfun Ide, Y. Sinan Sirin, H. Levent Keskin, A. Filiz Avşar, Işık Üstüner |
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| Rok vydání: | 2012 |
| Předmět: |
STERILE SALINE SOLUTION
medicine.medical_treatment Thiazines Adhesion (medicine) Tissue Adhesions Meloxicam Laparotomy medicine Animals Single-Blind Method Rats Wistar Tromethamine Inflammation Task force business.industry Anti-Inflammatory Agents Non-Steroidal Uterus Obstetrics and Gynecology Uterine horns Postoperative adhesion Dexketoprofen medicine.disease Rats Thiazoles Ketoprofen Anesthesia Female Collagen business medicine.drug |
| Zdroj: | Journal of minimally invasive gynecology. 20(2) |
| ISSN: | 1553-4669 |
| Popis: | Study Objective To compare the effects of 2 nonsteroidal antiinflammatory drugs of different chemical classes (meloxicam and dexketoprofen) on postoperative intraabdominal adhesion formation in a rat model. Design Experimental study (Canadian Task Force classification I). Setting Center for research and development. Animals Thirty female Wistar albino rats. Interventions The animals were randomly assigned to 1 of 3 groups (10 rats per group) and received intramuscular injections of 0.5 mg/kg dexketoprofen (group 1), 0.5 mg/kg meloxicam (group 2), or 1 mL sterile saline solution (control; group 3) daily for 2 days. Laparotomy was performed, and 1 of the uterine horns was damaged via monopolar electrocautery, whereas an incision was made in the other horn using a scalpel and was sutured to promote adhesion formation. The surgeons were blinded to the treatment method. Drug administration was continued for 5 days. The animals were euthanized at 14 days after surgery. Measurements and Main Results Intraperitoneal macroscopic and microscopic adhesions were assessed using standard adhesion scoring systems. Macroscopic adhesion scores were similar among the 3 groups in each horn (p > .50). The total histologic score was significantly lower in the meloxicam group than in the control group (8.0 vs 15.5; p = .006). Dexketoprofen did not significantly affect the total histologic score (11.0 vs 15.5; p = .09) or individual items (i.e., inflammation, fibroblastic activity, foreign body reaction, collagen formation, and vascular proliferation) compared with the control group (p > .02). Meloxicam significantly inhibited inflammation and collagen formation compared with the control group (p Conclusion Although meloxicam did not affect clinical adhesion formation, it significantly decreased histologic scores compared with those of the control group. Therefore, meloxicam may be suitable in reducing postoperative intraabdominal adhesion formation. |
| Databáze: | OpenAIRE |
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