Involved-field irradiation for elderly bladder cancer patients
| Autor: | Sujing Liu, Rukun Zang, Jinbo Ma, Wei Chen, Yipeng Song, Cun-Qi Li, Hongwei Li, Dong You |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male Cancer Research medicine.medical_specialty medicine.medical_treatment Urology Cystectomy 03 medical and health sciences 0302 clinical medicine medicine Chi-square test Humans Lymph node Aged Aged 80 and over Bladder cancer Lymphatic Irradiation business.industry Chemoradiotherapy medicine.disease Acute toxicity Clinical trial Radiation therapy Survival Rate 030104 developmental biology medicine.anatomical_structure Treatment Outcome Oncology Urinary Bladder Neoplasms 030220 oncology & carcinogenesis Toxicity Carcinoma Squamous Cell Female business Follow-Up Studies |
| Zdroj: | Current problems in cancer. 43(3) |
| ISSN: | 1535-6345 |
| Popis: | Objectives Considering that adjuvant radiation therapy is one of the most common treatment methods and the influence of the clinical target volume to treatment-related toxicity, this study aimed to observe the differences in treatment failures about involved-field irradiation (IFI) without lymph node areas versus elective nodal irradiation (ENI) with lymph node areas in elderly patients with bladder cancer. Material and Methods Ninety-two elderly bladder cancer patients were analyzed from January 2010 to December 2014 in one institution. The primary inclusion criteria were previous after transurethral resection of bladder tumor or partial cystectomy with adjuvant radiotherapy, and the radiation techniques included IFI or ENI. The study required that elderly patients did not received radiotherapy before treatment. We observed treatment-related toxicity and tumor failures, evaluated local progression-free survival, estimated the 3-year overall survival, and analyzed prognostic factors, after IFI and ENI in elderly bladder cancer patients. The outcomes were determined by chi square tests, Kaplan-Meier method and Cox multiple factors analysis. Results In the experimental group, 42 patients (45.65%) received IFI, and a matched group of 50 patients (54.35%) received ENI. With a median follow-up of 31.47 months (range 4.00-86.00 months), the Kaplan-Meier analysis with a log-rank test demonstrated a statistical difference between the IFI group and the ENI group in acute toxicity (45.23% vs 72.00%, P = 0.008). However, there were no statistical differences in the 3-year overall survival rate (45.20% vs 48.00%, P = 0.860) or the duration of local progression-free survival (24.98 vs 34.30, P =0.729). Conclusions IFI is feasible in elderly bladder cancer patients, as shown by a decrease in acute toxicity and no increase in local failure. We need a large number of clinical trials and data to further confirm these results. |
| Databáze: | OpenAIRE |
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