Amlodipine Reduces Blood Pressure and Hadache Fquency in Cocaine-Dependent Outpatients
| Autor: | Derik E. Yeager, Kristina Cochran, Robert Malcolm, Melissa Michel, Wesley Pye, Jiangang (Jason) Liao, Perry V. Halushka |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Adult
Male Diastole Medicine (miscellaneous) Hemodynamics Blood Pressure Neurological disorder Placebo Cocaine dependence Cocaine-Related Disorders Double-Blind Method Outpatients medicine Humans Poisson Distribution Amlodipine General Psychology Chi-Square Distribution business.industry Headache Middle Aged medicine.disease Blood pressure Anesthesia Female Headaches medicine.symptom business medicine.drug |
| Zdroj: | Journal of Psychoactive Drugs. 34:415-419 |
| ISSN: | 2159-9777 0279-1072 |
| DOI: | 10.1080/02791072.2002.10399983 |
| Popis: | Blood pressure and headache frequency were evaluated in normotensive male and female cocaine-dependent patients (N=43) participating in a placebo-controlled, double-blind trial of amlodipine for the treatment of cocaine dependence. Amlodipine produced a significant reduction in both systolic (p=0.04) and diastolic (p=0.01) blood pressures without producing dizziness or faintness. Placebo subjects had about three times the frequency of headaches compared to the amlodipine-treated subjects (p=0.004). The high frequency of headaches reported by cocaine-dependent individuals was significantly reduced by amlodipine and may reflect improved cerebrovascular tone. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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