Dominant inheritance of large molecular weight immunoreactive glucagon
| Autor: | John W. Ensinck, J W Benson, Jerry P. Palmer, Phillip L. Werner |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Adult
Male medicine.medical_specialty Large molecular weight Adolescent Arginine Size-exclusion chromatography Biology Glucagon Internal medicine medicine Humans Child Aged Genes Dominant Antiserum Glucose tolerance test medicine.diagnostic_test General Medicine Glucose Tolerance Test Middle Aged Pedigree Molecular Weight Endocrinology Chromatography Gel Female Three generations Dominant inheritance Research Article |
| Zdroj: | Journal of Clinical Investigation. 61:763-769 |
| ISSN: | 0021-9738 |
| DOI: | 10.1172/jci108990 |
| Popis: | Plasma from some individuals contains substances which are reactive with glucagon antiserum, are larger than 3,500-dalton glucagon, and have been proposed as possible precursors of glucagon. We have evaluated three generations of a kindred in which 9 of 15 members evaluated had elevated plasma levels of large molecular weight immunoreactive glucagon (L-IRG) with an average concentration of 822 pg/ml. The distribution of individuals with elevated L-IRG levels in this pedigree is consistent with autosomal dominant inheritance. Gel filtration of plasma revealed that all affected family members had excessive amounts of two L-IRG peaks, one with a molecular weight of approximately 9,000 daltons and another in the 10,000 to 20,000-dalton range. Oral glucose tolerance tests were nondiabetic and elicited a fall in L-IRG levels, whereas L-IRG concentrations rose dramatically during the infusion of arginine. These L-IRG species may be precursors of 3,500-DALTON GLUCAGON AND MAY BE ELEVATED in this kindred because of an inherited defect in either their synthesis or degradation. |
| Databáze: | OpenAIRE |
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