The Signaling Role of CD40 Ligand in Platelet Biology and in Platelet Component Transfusion
| Autor: | Bruno Pozzetto, Olivier Garraud, Hind Hamzeh-Cognasse, Chaker Aloui, Sandrine Laradi, Antoine Prigent, Caroline Sut, Fabrice Cognasse, Yolande Richard, Sofiane Tariket |
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| Přispěvatelé: | Groupe Immunité des Muqueuses et Agents Pathogènes (GIMAP), Université Jean Monnet [Saint-Étienne] (UJM), Institut Cochin (IC UM3 (UMR 8104 / U1016)), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM) |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Blood Platelets
chemical and pharmacologic phenomena Platelet Transfusion Review 030204 cardiovascular system & hematology Biology Models Biological Catalysis Inorganic Chemistry lcsh:Chemistry 03 medical and health sciences 0302 clinical medicine medicine CD40 Humans Platelet Platelet activation Physical and Theoretical Chemistry CD40 Antigens Receptor Molecular Biology lcsh:QH301-705.5 Spectroscopy ComputingMilieux_MISCELLANEOUS 030304 developmental biology 0303 health sciences Organic Chemistry p38 mitogen-activated protein kinases (MAPK) nuclear factor-KappaB (NF-κB) [SDV.MHEP.HEM]Life Sciences [q-bio]/Human health and pathology/Hematology hemic and immune systems General Medicine Acquired immune system medicine.disease signaling pathways 3. Good health Computer Science Applications Cell biology Platelet transfusion [SDV.IMM.IA]Life Sciences [q-bio]/Immunology/Adaptive immunology lcsh:Biology (General) lcsh:QD1-999 inflammation [SDV.IMM]Life Sciences [q-bio]/Immunology Signal transduction CD40 ligand Platelet factor 4 Transfusion-related acute lung injury Signal Transduction |
| Zdroj: | International Journal of Molecular Sciences, Vol 15, Iss 12, Pp 22342-22364 (2014) International Journal of Molecular Sciences International Journal of Molecular Sciences, MDPI, 2014, 15 (12), pp.22342-22364. ⟨10.3390/ijms151222342⟩ |
| ISSN: | 1422-0067 1661-6596 |
| DOI: | 10.3390/ijms151222342⟩ |
| Popis: | The CD40 ligand (CD40L) is a transmembrane molecule of crucial interest in cell signaling in innate and adaptive immunity. It is expressed by a variety of cells, but mainly by activated T-lymphocytes and platelets. CD40L may be cleaved into a soluble form (sCD40L) that has a cytokine-like activity. Both forms bind to several receptors, including CD40. This interaction is necessary for the antigen specific immune response. Furthermore, CD40L and sCD40L are involved in inflammation and a panoply of immune related and vascular pathologies. Soluble CD40L is primarily produced by platelets after activation, degranulation and cleavage, which may present a problem for transfusion. Soluble CD40L is involved in adverse transfusion events including transfusion related acute lung injury (TRALI). Although platelet storage designed for transfusion occurs in sterile conditions, platelets are activated and release sCD40L without known agonists. Recently, proteomic studies identified signaling pathways activated in platelet concentrates. Soluble CD40L is a good candidate for platelet activation in an auto-amplification loop. In this review, we describe the immunomodulatory role of CD40L in physiological and pathological conditions. We will focus on the main signaling pathways activated by CD40L after binding to its different receptors. |
| Databáze: | OpenAIRE |
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