Transposon mutagenesis of group B streptococcus beta-hemolysin biosynthesis
| Autor: | Craig E. Rubens, J N Weiser |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Transposable element
Immunology Mutant Virulence Biology Hemolysin Proteins medicine.disease_cause Microbiology Virulence factor Streptococcus agalactiae Streptococcal Infections medicine Animals Genetics Hemolysin Rats Infectious Diseases Animals Newborn Mutation DNA Transposable Elements Parasitology Transposon mutagenesis Research Article |
| Zdroj: | Infection and Immunity. 55:2314-2316 |
| ISSN: | 1098-5522 0019-9567 |
| DOI: | 10.1128/iai.55.9.2314-2316.1987 |
| Popis: | Beta-hemolysin production by group B streptococci (GBS) is speculated to be a major virulence factor of the organism. A virulent, beta-hemolytic group B streptococcus strain was mutagenized with the self-conjugative transposon Tn916 to derive isogenic strains with mutations only in the gene(s) responsible for beta-hemolysin biosynthesis. There was no significant difference between the virulence of the parent strain and that of the mutant strains in a neonatal rat sepsis model. |
| Databáze: | OpenAIRE |
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