Evaluation of 13-week repeated oral dose toxicity of Areca catechu in F344/N rats
| Autor: | Je-Won Ko, Mi-Jin Cha, Si-Whan Song, Jong-Choon Kim, Seung-Beom Cha, Hyun-Ji Kim, Jong-Hun Seo, Hyun-Suk Heo, Hyun-Kul Lee, Jin-Sook Bae |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Urinalysis Administration Oral Physiology Catechu Kidney Toxicology 03 medical and health sciences 0302 clinical medicine Oral administration medicine Animals Areca Estrous cycle No-Observed-Adverse-Effect Level Dose-Response Relationship Drug Sperm Count medicine.diagnostic_test biology Plant Extracts business.industry Reproduction Alanine Transaminase Organ Size General Medicine biology.organism_classification Rats Inbred F344 Rats 030104 developmental biology Liver 030220 oncology & carcinogenesis Toxicity Sperm Motility Alkaline phosphatase Female Histopathology business Food Science |
| Zdroj: | Food and Chemical Toxicology. 114:41-51 |
| ISSN: | 0278-6915 |
| DOI: | 10.1016/j.fct.2018.02.015 |
| Popis: | This study investigated the potential toxicity of the Areca catechu water extract after 13-week repeated oral administration at 0, 166.7, 500, and 1500 mg/kg/day in rats. During the study period, clinical signs, mortality, body weight, food consumption, water consumption, urinalysis, estrous cycle, sperm count and motility, ophthalmoscopy, hematology, serum biochemistry, gross pathology, organ weights, and histopathology were examined. At 1500 mg/kg/day, both sexes exhibited an increase in the incidence of abnormal clinical signs, which included, decreased body weight gain and food consumption, and increased urine bilirubin, ketone bodies, specific gravity, and protein and kidney weight. An increase in liver weight and estrous cycle alterations was observed in females. Serum biochemical and histopathological investigations revealed an increase in the levels of serum aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase, and the incidence of hepatic necrosis in females. At 500 mg/kg/day, an increase in the incidence of abnormal clinical signs including diarrhea and soiled perineal region, was observed in both sexes. No treatmentrelated effects were observed at 166.7 mg/kg/day. Under the present experimental conditions, the target organs were determined to be the liver, kidney, and female reproductive system in rats. The no-observedeffect level was considered to be 166.7 mg/kg/day in rats. |
| Databáze: | OpenAIRE |
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