Association of lipid profile with decompensation, liver dysfunction, and mortality in patients with liver cirrhosis
| Autor: | Ruirui Feng, Xiangbo Xu, Yun Kou, Andrea Mancuso, Cyriac Abby Philips, Xingshun Qi, Yang An, Wenwen Zhang, Xiaozhong Guo, Cen Hong |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Liver Cirrhosis
Male China medicine.medical_specialty Cirrhosis 030209 endocrinology & metabolism 030204 cardiovascular system & hematology Gastroenterology 03 medical and health sciences 0302 clinical medicine Liver Function Tests Predictive Value of Tests Internal medicine Outcome Assessment Health Care Humans Medicine Decompensation In patient Triglycerides medicine.diagnostic_test business.industry Cholesterol HDL Lipid metabolism Cholesterol LDL General Medicine Middle Aged Lipid Metabolism Prognosis medicine.disease Survival Analysis Cholesterol Cross-Sectional Studies Research Design Female lipids (amino acids peptides and proteins) Liver dysfunction business Lipid profile Dyslipidemia Lipoprotein(a) |
| Zdroj: | Postgraduate Medicine. :1-13 |
| ISSN: | 1941-9260 0032-5481 |
| DOI: | 10.1080/00325481.2021.1930560 |
| Popis: | Lipid metabolism is often disrupted in liver cirrhosis. The present study aimed to evaluate the impact of lipid profile on decompensation events, severity of liver dysfunction, and death in patients with liver cirrhosis.In a cross-sectional study, 778 patients with lipid profile data were enrolled, and then were divided into 240 and 538 patients with and without liver cirrhosis, respectively. In a cohort study, 314 cirrhotic patients with lipid profile data, who were prospectively followed, were enrolled. Lipid profile included total cholesterol (TC), high-density lipoprotein-cholesterol (HDL-c), low-density lipoprotein-cholesterol (LDL-c), triglycerides (TG), and lipoprotein(a).In the cross-sectional study, cirrhotic patients with decompensation events had significantly lower levels of TC and lipoprotein(a) than those without; and cirrhotic patients with Child-Pugh class B and C had significantly lower levels of TC, HDL-c, LDL-c, and lipoprotein(a) than those with Child-Pugh class A. In the cohort study, there was an inverse association of survival with TC, HDL-c, and lipoprotein(a) levels; after adjusting for MELD score, TC (Hazard Ratio [HR] = 1.703, P = 0.034) and HDL-c (HR = 2.036, P = 0.005), but not lipoprotein(a) (HR = 1.377, P = 0.191), remained a significant predictor of death; when TC, HDL-c, lipoprotein(a), and MELD score were included in the multivariate Cox regression analysis, HDL-c (HR = 1.844, P = 0.024) was the only independent predictor of death.Decreased levels in specific components of lipid profile indicate more decompensation events, worse liver function, and reduced survival in liver cirrhosis. MELD score combined with HDL-c should be promising for the assessment of outcomes of cirrhotic patients. |
| Databáze: | OpenAIRE |
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