Endometriosis is associated with central sensitization: a psychophysical controlled study
| Autor: | Prem Bajaj, Lars Arendt-Nielsen, Priti Bajaj, Hans Madsen |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
Pain Threshold Endometriosis Pain Injections Intramuscular Multifidus muscle Physical Stimulation Psychophysics medicine Humans Pain Measurement Saline Solution Hypertonic Referred pain business.industry Pelvic pain medicine.disease Hypertonic saline Anesthesiology and Pain Medicine Nociception Neurology Hyperalgesia Anesthesia Nociceptor Female Neurology (clinical) medicine.symptom business |
| Zdroj: | The Journal of Pain. 4:372-380 |
| ISSN: | 1526-5900 |
| DOI: | 10.1016/s1526-5900(03)00720-x |
| Popis: | Endometriosis is a pain syndrome representing a major cause of pelvic pain in women of reproductive age. The aim of this study was to test the hypothesis that persistent nociceptive input from endometriotic tissues leads to central sensitization manifested by somatic hyperalgesia and increased referred pain areas to experimental saline-induced muscle pain in patients with endometriosis, compared to healthy control subjects. Ten women with laparoscopically confirmed endometriosis and 10 healthy, age-matched women participated in the study. Hypertonic saline (0.5 mL, 5.8%) was injected intramuscularly, in random succession, into 1 site of menstrual pain referral (the multifidus muscle at the low back) and into 1 non-pain control site (first dorsal interosseous muscle [FDI] of the hand). The post-saline pain intensity and pain areas at the FDI were significantly greater in patients with endometriosis than in control subjects (P |
| Databáze: | OpenAIRE |
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