Standard operating procedure for immunuslotblot assay for analysis of DNA/sulfur mustard adducts in human blood and skin
| Autor: | L.P.A. de Jong, Daan Noort, Roos H. Mars-Groenendijk, G.P. van der Schans, Hendrik P. Benschop |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
inorganic chemicals
Stereochemistry Health Toxicology and Mutagenesis Immunoblotting Human skin Toxicology Biological fluid Analytical Chemistry Adduct chemistry.chemical_compound DNA Adducts Reference Values Mustard Gas Leukocytes Environmental Chemistry Humans Chemical Warfare Agents Military Medicine Skin Chemical Health and Safety Chromatography integumentary system Human blood Chemistry Sulfur mustard In vitro Reference values DNA |
| Zdroj: | Journal of analytical toxicology. 28(5) |
| ISSN: | 0146-4760 |
| Popis: | A standard operating procedure has been developed for an immunoslotblot assay of sulfur mustard adducts to DNA in human blood and skin for use in a field laboratory. A minimum detectable level of exposure of human blood in vitro (> or = 50 nM) sulfur mustard is feasible with the assay. In the case of human skin, a 1 s exposure to saturated sulfur mustard vapor (830 mg/m(-3)) could still be detected. |
| Databáze: | OpenAIRE |
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