spict, a cyst cell-specific gene, regulates starvation-induced spermatogonial cell death in the Drosophila testis
| Autor: | Heiko Yang, Ason C.Y. Chiang, Yukiko M. Yamashita |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male Programmed cell death Cellular differentiation Biology Article 03 medical and health sciences Downregulation and upregulation Phagocytosis Testis medicine Animals Drosophila Proteins Cyst Tissue homeostasis Multidisciplinary Cell Death Cysts Membrane Proteins Cell Differentiation medicine.disease Spermatogonia Cell biology 030104 developmental biology Starvation Drosophila Stem cell Homeostasis Drosophila Protein |
| Zdroj: | Scientific Reports |
| ISSN: | 2045-2322 |
| Popis: | Tissues are maintained in a homeostatic state by balancing the constant loss of old cells with the continued production of new cells. Tissue homeostasis can shift between high and low turnover states to cope with environmental changes such as nutrient availability. Recently, we discovered that the elimination of transit-amplifying cells plays a critical role in maintaining the stem cell population during protein starvation in the Drosophila testis. Here, we identify spict, a gene expressed specifically in differentiating cyst cells, as a regulator of spermatogonial death. Spict is upregulated in cyst cells that phagocytose dying spermatogonia. We propose that phagocytosis and subsequent clearance of dead spermatogonia, which is partly promoted by Spict, contribute to stem cell maintenance during prolonged protein starvation. |
| Databáze: | OpenAIRE |
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