Organic Cation Transporters in the Lung—Current and Emerging (Patho)Physiological and Pharmacological Concepts
| Autor: | Johannes A. Sake, Johanna J. Salomon, Carsten Ehrhardt, Mohammed Ali Selo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Gene Expression Endogeny Review Pharmacology 030226 pharmacology & pharmacy lcsh:Chemistry chemistry.chemical_compound 0302 clinical medicine drug uptake Homeostasis Protein Isoforms Lung lcsh:QH301-705.5 Spectroscopy media_common Organic cation transport proteins biology Chemistry General Medicine Computer Science Applications medicine.anatomical_structure Ergothioneine Disease Susceptibility pulmonary drug delivery Drug SLC22A1–5 Organic Cation Transport Proteins media_common.quotation_subject Respiratory Mucosa Catalysis Inorganic Chemistry lung epithelium 03 medical and health sciences Pharmacological Concepts medicine Animals Humans anticholinergics Physical and Theoretical Chemistry Molecular Biology Organic Chemistry Biological Transport Transporter Solute carrier family 030104 developmental biology lcsh:Biology (General) lcsh:QD1-999 biology.protein chronic lung diseases β2-agonists |
| Zdroj: | International Journal of Molecular Sciences, Vol 21, Iss 9168, p 9168 (2020) International Journal of Molecular Sciences |
| ISSN: | 1661-6596 1422-0067 |
| Popis: | Organic cation transporters (OCT) 1, 2 and 3 and novel organic cation transporters (OCTN) 1 and 2 of the solute carrier 22 (SLC22) family are involved in the cellular transport of endogenous compounds such as neurotransmitters, l-carnitine and ergothioneine. OCT/Ns have also been implicated in the transport of xenobiotics across various biological barriers, for example biguanides and histamine receptor antagonists. In addition, several drugs used in the treatment of respiratory disorders are cations at physiological pH and potential substrates of OCT/Ns. OCT/Ns may also be associated with the development of chronic lung diseases such as allergic asthma and chronic obstructive pulmonary disease (COPD) and, thus, are possible new drug targets. As part of the Special Issue “Physiology, Biochemistry and Pharmacology of Transporters for Organic Cations”, this review provides an overview of recent findings on the (patho)physiological and pharmacological functions of organic cation transporters in the lung. |
| Databáze: | OpenAIRE |
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