An observational study of hospitalized COVID-19 patients with cancer in San Diego county
| Autor: | David J Hermel, Jason Cham, Samantha R Spierling Bagsic, Lee K Hong, Carrie L Costantini, James R Mason, Alan Saven, Darren S Sigal |
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| Rok vydání: | 2022 |
| Předmět: |
Aged
80 and over Male Cancer Research Lung Neoplasms SARS-CoV-2 Patient Acuity COVID-19 Antineoplastic Agents General Medicine Middle Aged California Hospitalization Oncology Neoplasms Humans Immunologic Factors Female Molecular Targeted Therapy Immune Checkpoint Inhibitors Aged Retrospective Studies |
| Zdroj: | Future oncology (London, England). 18(6) |
| ISSN: | 1744-8301 |
| Popis: | Aim: To delineate clinical correlates of COVID-19 infection severity in hospitalized patients with malignancy. Methods: The authors conducted a retrospective review of all hospitalized patients with a hematologic and/or solid tumor malignancy presenting to the authors' institution between 1 March 2020 and 5 January 2021, with a laboratory confirmed diagnosis of COVID-19. Univariate and multivariate logistic regression analyses were used to determine associations between specific severity outcomes and clinical characteristics. Results: Among 2771 hospitalized patients with COVID-19, 246 (8.88%) met inclusion criteria. Patients who were actively receiving treatment had an increased rate of death following admission (odds ratio [OR]: 2.7). After adjusting for significant covariates, the odds ratio increased to 4.4. Patients with cancer involvement of the lungs had a trend toward increased odds of death after adjusting for covariates (OR: 2.3). Conclusions: Among COVID-19 positive hospitalized cancer patients, systemic anti-cancer therapy was associated with significantly increased odds of mortality. |
| Databáze: | OpenAIRE |
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