Reproducibility of Circumpapillary Retinal Nerve Fiber Layer Measurements Using Handheld Optical Coherence Tomography in Sedated Children
| Autor: | Chieh-Li Chen, Hiroshi Ishikawa, Roger J. Packer, Joel S. Schuman, Robert A. Avery, Avital Cnaan, Graham E. Quinn, Natalie C. Glaug |
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| Rok vydání: | 2014 |
| Předmět: |
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Optic Nerve Glioma Retinal Ganglion Cells medicine.medical_specialty Neurofibromatosis 1 Adolescent genetic structures Intraclass correlation Optic Disk Conscious Sedation Optic disk Nerve fiber layer Article Nerve Fibers Optical coherence tomography Ophthalmology medicine Humans Longitudinal Studies Prospective Studies Child Prospective cohort study Reproducibility medicine.diagnostic_test business.industry Infant Reproducibility of Results medicine.disease eye diseases Surgery Cross-Sectional Studies medicine.anatomical_structure Child Preschool Optic nerve Female sense organs Optic nerve glioma business Tomography Optical Coherence |
| Zdroj: | American Journal of Ophthalmology. 158:780-787.e1 |
| ISSN: | 0002-9394 |
| DOI: | 10.1016/j.ajo.2014.06.017 |
| Popis: | Purpose To determine the intra- and intervisit reproducibility of circumpapillary retinal nerve fiber layer (RNFL) measures using handheld optical coherence tomography (OCT) in sedated children. Design Prospective cross-sectional and longitudinal study. Methods Children undergoing sedation for a clinically indicated magnetic resonance imaging for an optic pathway glioma and/or neurofibromatosis type 1 (NF1) had multiple 6 × 6 mm volumes (isotropic 300 × 300 or nonisotropic 1000 × 100 samplings) acquired over the optic nerve. Children with 2 handheld OCT sessions within 6 months were included in the intervisit cohort. The intra- and intervisit coefficient of variation (CV) and intraclass correlation coefficient (ICC) were calculated for the average and anatomic quadrant circumpapillary RNFL thickness. Results Fifty-nine subjects (mean age 5.1 years, range 0.8–13.0 years) comprised the intravisit cohort and 29 subjects (mean age 5.7 years, range 1.8–12.7 years) contributed to the intervisit cohort. Forty-nine subjects had an optic pathway glioma and 10 subjects had NF1 without an optic pathway glioma. The CV was comparable regardless of imaging with an isotropic and nonisotropic volume in both the intra- and intervisit cohorts. The average circumpapillary RNFL demonstrated the lowest CV and highest ICC compared to the quadrants. For the intervisit cohort, the average ICC was typically higher while the CV was typically lower, but not statistically different compared to the other quadrants. Discussion Circumpapillary RNFL measures acquired with handheld OCT during sedation demonstrate good intra- and intervisit reproducibility. Handheld OCT has the potential to monitor progressive optic neuropathies in young children who have difficulty cooperating with traditional OCT devices. |
| Databáze: | OpenAIRE |
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