Lipophilic chelator inhibition of electron transport in Escherichia coli
| Autor: | I L Sun, R T Crane, F L Crane |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
Vitamin K
Reduced nicotinamide-adenine dinucleotide Biology Cell Fractionation medicine.disease_cause Microbiology Electron Transport Escherichia coli medicine NADH NADPH Oxidoreductases Chelation Quinone Reductases Molecular Biology Chelating Agents Oxidase test Uncoupling Agents Cell Membrane Electron transport chain Hydroquinones Alcohol Oxidoreductases Membrane Biochemistry Depression Chemical Lactates Phosphorylation Duroquinol oxidase Phenanthrolines Research Article |
| Zdroj: | Journal of Bacteriology. 122:686-690 |
| ISSN: | 1098-5530 0021-9193 |
| DOI: | 10.1128/jb.122.2.686-690.1975 |
| Popis: | The lipophilic chelator bathophenanthroline inhibits electron transport in membranes from Escherichia coli. The less lipophilic 1,10-phenanthroline, bathophenanthroline sulfonate, and alpha,alpha-dipyridyl have little effect. Reduced nicotinamide adenine dinucleotide oxidase is more sensitive to bathophenanthroline inhibition than lactate oxidase activity. Evidence for two sites of inhibition comes from the fact that both reduced nicotinamide adenine dinucleotide menadione reductase and duroquinol oxidase activities are inhibited. Addition of uncouplers of phosphorylation before bathophenanthroline protects against inhibition. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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