Reduction-Responsive Chemo-Capsule-Based Prodrug Nanogel for Synergistic Treatment of Tumor Chemotherapy
| Autor: | Yuejun Kang, Mengyun Liang, Shengxin Hou, Peng Xue, Die Jia, Yuan Gao, Wei Qiu, Yi Lu, Xianbin Ma, Zhigang Xu |
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| Rok vydání: | 2021 |
| Předmět: |
Drug
Materials science Cell Survival Surface Properties media_common.quotation_subject medicine.medical_treatment Nanogels Antineoplastic Agents Capsules 02 engineering and technology 010402 general chemistry 01 natural sciences Polyethylene Glycols Mice In vivo Cell Line Tumor medicine Tumor Microenvironment Animals Humans Polyethyleneimine General Materials Science Doxorubicin Prodrugs Particle Size media_common Cell Proliferation Chemotherapy Tumor microenvironment Prodrug 021001 nanoscience & nanotechnology 0104 chemical sciences Drug Liberation Cross-Linking Reagents Cancer research Camptothecin Drug Screening Assays Antitumor 0210 nano-technology Oxidation-Reduction medicine.drug Nanogel DNA Damage |
| Zdroj: | ACS applied materialsinterfaces. 13(7) |
| ISSN: | 1944-8252 |
| Popis: | Chemotherapy is currently the most universal therapeutics to tumor treatment; however, limited curative effect and undesirable drug resistance effect are the two major clinical bottlenecks. Herein, we develop a two-in-one cross-linking strategy to prepare a stimuli-responsive prodrug nanogel by virtue of delivering a combination of chemotherapeutic drugs of 10-hydroxy camptothecin and doxorubicin for ameliorating the deficiencies of chemotherapy and amplifying the cancer therapeutic efficiency. The obtained prodrug nanogel has both high drug loading capacity and suitable nanoscale size, which are beneficial to the cell uptake and tumor penetration. Moreover, the chemotherapeutic drugs are released from the prodrug nanogel in response to the reductive tumor microenvironment, enhancing tumor growth inhibition in vitro and in vivo by the synergistic DNA damage. Based on these results, the unique prodrug nanogel would be a promising candidate for satisfactory tumor treatment-based chemotherapy by a simple but efficient strategy. |
| Databáze: | OpenAIRE |
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